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首页> 外文期刊>Analytical methods >Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with a porphyrin-based porous organic polymer modified capillary
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Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with a porphyrin-based porous organic polymer modified capillary

机译：卟啉基多孔有机聚合物修饰毛细管在线固相微萃取技术灵敏测定补骨脂中补骨脂素和异补骨脂素的含量

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摘要

A novel porphyrin based porous organic polymer modified capillary (PPOP-capillary) was prepared for the extraction of psoralen and isopsoralen in Fructus Psoraleae. Fructus Psoraleae is an important traditional Chinese medicine in clinical therapy. Sensitive and effective extraction and determination of psoralen and isopsoralen benefit the quality control in Fructus Psoraleae and related preparations. PPOPs were immobilized on the inner wall of the capillary by a bottom-up approach. The formation of PPOPs has been confirmed by scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. An online solid phase microextraction coupled with HPLC method was developed for selective extraction and analysis of psoralen and isopsoralen in aqueous solutions. The proposed method showed a good linear range of 0.05–100 ng mL?1 with a low limit of detection of 0.01 ng mL?1. The method was also applied for the extraction of psoralen and isopsoralen in Fructus Psoraleae, which showed high enrichment efficiency and good clean-up capacity. Recoveries were calculated to be 93.3–96.7% with relative standard deviations less than 1.6%.
机译：制备了一种新型的卟啉基多孔有机聚合物修饰毛细管（PPOP-毛细管），用于提取补骨脂中的补骨脂素和异补骨脂素。补骨脂是临床上重要的中药。灵敏有效的提取和测定补骨脂素和异补骨脂素有利于补骨脂及其相关制剂的质量控制。通过自下而上的方法将PPOPs固定在毛细管的内壁上。通过扫描电子显微镜，X射线衍射和傅立叶变换红外光谱已确认了PPOP的形成。开发了一种在线固相微萃取-HPLC方法，用于水溶液中补骨脂素和异补骨脂素的选择性提取和分析。所提出的方法显示出良好的线性范围0.05–100 ng mL？1，检测下限为0.01 ng mL？1。该方法还适用于补骨脂中补骨脂素和异补骨脂素的提取，具有较高的富集效率和良好的净化能力。计算的回收率为93.3–96.7％，相对标准偏差小于1.6％。

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