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A surface plasmon resonance-based biochip to reveal traces of ephedrine

机译:一种基于表面等离子体共振的生物芯片,可显示出麻黄碱的痕迹

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Ephedrineisacrucialchemicalprecursorforclandestinelyproducedamphetamineanditsrelateddrugs.Also,ephedrineisintentionallyaddedtoillegalpreparationsofmethamphetamineoramphetaminebecauseitischeaperthantheothertwodrugs.Consequentlythereisapressingneedtopreventtheentryofephedrineintocommerce.Thereforethechallengecallsfornon-invasivetechniquesthatprovidedataonthepresenceofephedrineevenintraceamounts.Inthispaperwedescribethesynthesisofanewephedrinederivativewithacarbonlinkerfeaturinganaminoreactivegroup,anditsconjugationtotheglutaminebindingprotein(GlnBP)fromE.coliasacarrierproteinfortheproductionofpolyclonalantibodiesagainstephedrine.Proof-of-principleresultsofanefficientSPR-basedindirectcompetitiveimmunoassayforthedetectionandquantificationofephedrinearepresented.Thedetectionlimitoftheassaywasabout33ngml?1...
机译:Ephedrineisacrucialchemicalprecursorforclandestinelyproducedamphetamineanditsrelateddrugs.Also,ephedrineisintentionallyaddedtoillegalpreparationsofmethamphetamineoramphetaminebecauseitischeaperthantheothertwodrugs.Consequentlythereisapressingneedtopreventtheentryofephedrineintocommerce.Thereforethechallengecallsfornon-invasivetechniquesthatprovidedataonthepresenceofephedrineevenintraceamounts.Inthispaperwedescribethesynthesisofanewephedrinederivativewithacarbonlinkerfeaturinganaminoreactivegroup,anditsconjugationtotheglutaminebindingprotein(GlnBP)principleresultsofanefficientSPR-basedindirectcompetitiveimmunoassayforthedetectionandquantificationofephedrinearepresented.Thedetectionlimitoftheassaywasabout33ngml fromE.coliasacarrierproteinfortheproductionofpolyclonalantibodiesagainstephedrine.Proof - 的 - ?1 ...

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