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首页> 外文期刊>Annals of Gastroenterological Surgery >Obesity and recurrence‐free survival in patients with hepatocellular carcinoma after achieving sustained virological response to interferon therapy for chronic hepatitis C
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Obesity and recurrence‐free survival in patients with hepatocellular carcinoma after achieving sustained virological response to interferon therapy for chronic hepatitis C

机译：在对慢性丙型肝炎的干扰素治疗实现持续病毒学应答后，肝细胞癌患者的肥胖和无复发生存

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Aim Some patients who achieve a sustained virological response (SVR) to interferon (IFN) treatment for chronic hepatitis C prior to hepatic resection for hepatocellular carcinoma (HCC) experience postoperative recurrence. This study investigated the relationship between obesity and postoperative HCC recurrence in SVR patients. Methods Fifty‐nine patients who had achieved SVR before hepatic resection were evaluated. Patients had a solitary tumor ≤5 cm in diameter or ≤3 lesions each ≤3 cm in size with no macroscopic vascular invasion (Milan criteria). Patient characteristics potentially associated with recurrence risk were investigated. Results Three‐, 5‐, and 7‐year recurrence‐free survival after surgery were 65%, 44%, and 41%, respectively. Univariate analysis showed that obesity ( P Conclusions Obesity and non‐anatomical resection were independent risk factors for HCC recurrence after hepatic resection and successful IFN therapy. Obesity is an important clinical problem to consider to improve postoperative outcomes in such patients.
机译：目的一些在肝癌切除术之前对慢性丙型肝炎达到对干扰素（IFN）治疗持续的病毒学应答（SVR）的患者，术后会复发。这项研究调查了肥胖与SVR患者术后HCC复发之间的关系。方法对59例在肝切除之前达到SVR的患者进行评估。患者患有孤立的肿瘤，直径≤5cm或≤3个病变，每个≤3cm，无肉眼可见的血管侵犯（米兰标准）。研究了可能与复发风险相关的患者特征。结果术后三年，五年和七年无复发生存率分别为65％，44％和41％。单因素分析表明，肥胖（P结论肥胖和非解剖切除是肝切除和成功IFN治疗后HCC复发的独立危险因素。肥胖是改善此类患者术后结局的重要临床问题。

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