• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Analytical Sciences >Chiral Separation of Sertraline with Microemulsion Electrokinetic Chromatography on a Polymer/β-cyclodextrin Assembling Molecular Film Modified Capillary
【24h】

Chiral Separation of Sertraline with Microemulsion Electrokinetic Chromatography on a Polymer/β-cyclodextrin Assembling Molecular Film Modified Capillary

机译：聚合物/ β-环糊精组装分子膜修饰的毛细管微乳液动力学色谱法手性分离舍曲林

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A capillary modified by assembling a molecular film was presented for the chiral separation of sertraline by microemulsion electrokinetic chromatography. The assembling molecular film was constructed with poly(diallyldimethylammonium-chloride) and β -cyclodextrin via inclusion complexation. The separation efficiency of cis-trans isomers and enantiomers of sertraline was improved with a running microemulsion that contained the acetonitrile, sodium dodecyl sulfate, n -butanol and n -hexane buffered with sodium tetraborate. The baseline separation of four sertraline cis-trans isomers and enantiomers was achieved under the optimum conditions. The detection limit for isomers and enantiomers of sertraline (1S ,4S , 1R ,4R , 1S ,4R , 1R ,4S ) was 0.15, 0.15, 0.30, 0.30 mg/L, respectively. The mechanism of chiral separation was studied and it could be applied for the determination of commercial Zoloft tablet samples satisfactorily.
机译：提出了通过组装分子膜改性的毛细管，用于通过微乳液电动色谱手性分离舍曲林。通过包合络合用聚二烯丙基二甲基氯化铵和β-环糊精构建组装分子膜。用运行的微乳液提高了舍曲林的顺反异构体和对映异构体的分离效率，该微乳液包含乙腈，十二烷基硫酸钠，正丁醇和正己烷缓冲的四硼酸钠。在最佳条件下，实现了四种舍曲林顺​​反异构体和对映异构体的基线分离。舍曲林（1S，4S，1R，4R，1S，4R，1i的异构体和对映体的检测限R，4S）分别为0.15、0.15、0.30、0.30mg / L。研究了手性分离的机理，可以令人满意地用于商业化的Zoloft片剂样品的测定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号