Simultaneous Determination of Dextromethorphan and Its Metabolite Dextrorphan in Plasma Samples Using Second-order Calibration Coupled with Excitation-Emission Matrix Fluorescence

Ya-Juan LIU; Hai-Long WU; Jin-Fang NIE; Jian-Yao WANG; Li-Qun OUYANG; Ru-Qin YU

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Simultaneous Determination of Dextromethorphan and Its Metabolite Dextrorphan in Plasma Samples Using Second-order Calibration Coupled with Excitation-Emission Matrix Fluorescence

机译：二次校准与激发发射矩阵荧光法同时测定血浆样品中的右美沙芬及其代谢物右美沙芬

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Dextromethorphan (DEX) is an antitussive agent used in many cough and cold medications, and dextrorphan (DOR) is its metabolite. Owing to their similar structures, optimization of the condition for the chromatography approach, which is in common use for determination, is both demanding and time-consuming. This paper describes a methodology that combines excitation-emission matrix fluorescence spectra with second-order calibration, and was applied to simultaneously and directly determine DEX and DOR contents in plasma samples.

机译：右美沙芬（DEX）是一种止咳药，用于许多咳嗽和感冒药，右美沙芬（DOR）是其代谢产物。由于其相似的结构，通常用于测定的色谱方法条件的优化既费时又费时。本文介绍了一种将激发-发射矩阵荧光光谱与二阶校准相结合的方法，并应用于同时直接测定血浆样品中的DEX和DOR含量。

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《Analytical Sciences》 |2011年第6期|共4页
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Ya-Juan LIU; Hai-Long WU; Jin-Fang NIE; Jian-Yao WANG; Li-Qun OUYANG; Ru-Qin YU;
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中图分类分析化学;
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1. Simultaneous determination of dextromethorphan and quinidine contents in biological fluid samples using excitation-emission matrix fluorescence coupled with second-order calibration methods [J] . Zou H.-Y., Wu H.-L., Li Y.-N., Analytical Letters . 2010,第16a18期

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2. Rapid, simultaneous and interference-free determination of three rhodamine dyes illegally added into chilli samples using excitation-emission matrix fluorescence coupled with second-order calibration method [J] . Yue-Yue Chang, Hai-Long Wu, Huan Fang, Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy . 2018,第期

机译：使用激励 - 发射矩阵荧光与二阶校准方法相结合，非法添加到辣椒样品中的三种菱胺染料的快速，同时和干扰测定。
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4. Simultaneous determination of Benzokfluoranthene and Perylene using Excitation-Emission Matrix Fluorescence [C] . Huan-Bo Wang, Yu-Jun Zhang, Jing-Bo Duan, AOMATT 2010;International symposium on advanced optical manufacturing and testing technologies . 2011

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7. Simultaneous Determination of Dextromethorphan and Its Metabolite Dextrorphan in Plasma Samples Using Second-order Calibration Coupled with Excitation-Emission Matrix Fluorescence [O] . Ya-Juan LIU, Hai-Long WU, Jin-Fang NIE, 2011

机译：使用二阶校准与激发 - 发射矩阵荧光相结合的血浆样品中葡聚糖和其代谢物右旋甲烷的同时测定葡聚糖样品

Simultaneous Determination of Dextromethorphan and Its Metabolite Dextrorphan in Plasma Samples Using Second-order Calibration Coupled with Excitation-Emission Matrix Fluorescence

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