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Effects of Surface Nano-Topography on Human Osteoblast Filopodia

机译：表面纳米形貌对人成骨细胞丝足的影响

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Anchorage-dependent cells growing over a substratum require stable adhesion areas on the surface for the next cellular activities. The adhesion is achieved by some contact points called focal adhesions. Because focal adhesions were distributed randomly, a trial to control the positions of focal adhesion with a specific order may cause interesting effects like as cytoskeleton rearrangement, which may induce and transfer new signals to the nucleus. Here, we cultured human osteoblasts over two sorts of nanopatterned surfaces with different pattern densities fabricated by using laser interference lithography and the nanoimprinting technique. Of the two nanopatterns, cells over the nanopattern with low pattern density showed relatively higher adaptation to the topography with guided filopodia protrusion. However, cells over the dense nanopattern showed difficulty in finding suitable paths for migration, as judged from the activities of filopodium formation and the presence of a shovel-like feature at the tip of each filopodium.
机译：生长在基质上的锚固依赖性细胞需要表面上稳定的粘附区域才能进行下一次细胞活动。粘附是通过一些称为粘着斑的接触点实现的。由于粘着斑是随机分布的，因此以特定顺序控制粘着斑位置的试验可能会引起有趣的效果，例如细胞骨架重排，这可能会诱导新信号并将其传递至核。在这里，我们通过激光干涉光刻和纳米压印技术在两种具有不同图案密度的纳米图案表面上培养人类成骨细胞。在这两种纳米图案中，纳米图案上具有低图案密度的细胞显示出相对较高的适应性，并伴有引导的丝状伪足突起。然而，从纤毛虫形成的活性以及在每个纤毛虫的尖端处存在铲状特征的判断，致密的纳米图案上的细胞显示出难以找到合适的迁移路径。

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