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NMR-based Metabolomic Analysis of Human Bladder Cancer

机译：基于NMR的人膀胱癌的代谢组学分析

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Bladder cancer (BC) is one of the most common cancers and has a high mortality rate. However, both metabolite variations and metabolic pathways related to the pathogenic process of BC remain to be addressed, such results might contribute to early detection of the disease. ~(1)H nuclear magnetic resonance (NMR)-based metabolomics was applied to identify differences of serum metabolic profiles among BC, calculi patients and healthy subjects. Serum metabolic profiles of BC patients are distinctly different from those of calculi and healthy subjects. Compared with those from healthy subjects, serum samples from BC patients show decreased levels of isoleucine/leucine, tyrosine, lactate, glycine, citrate, as well as increased levels of lipids and glucose. The results reveal disturbed metabolic pathways of aromatic amino acids, glycolysis and citrate cycle, as well as lipogenesis metabolism in BC patients. Our work will be of potential benefit to understanding the pathogenic process of BC and will offer valuable information for noninvasive diagnosis of the disease.
机译：膀胱癌（BC）是最常见的癌症之一，死亡率很高。然而，与BC的致病过程相关的代谢物变化和代谢途径仍有待解决，这些结果可能有助于疾病的早期发现。基于〜（1）H核磁共振（NMR）的代谢组学研究了BC，结石患者和健康受试者之间血清代谢谱的差异。 BC患者的血清代谢曲线与结石和健康受试者的血清代谢曲线明显不同。与健康受试者相比，BC患者的血清样本显示异亮氨酸/亮氨酸，酪氨酸，乳酸，甘氨酸，柠檬酸水平降低，脂质和葡萄糖水平升高。结果显示，BC患者芳香族氨基酸的代谢途径，糖酵解和柠檬酸盐循环以及脂肪生成代谢受到干扰。我们的工作将对理解BC的致病过程具有潜在的好处，并将为该病的非侵入性诊断提供有价值的信息。

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