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首页> 外文期刊>Annals of Thoracic Medicine >Performance of QuantiFERON-TB Gold test compared to tuberculin skin test in detecting latent tuberculosis infection in HIV- positive individuals in Iran
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Performance of QuantiFERON-TB Gold test compared to tuberculin skin test in detecting latent tuberculosis infection in HIV- positive individuals in Iran

机译：与伊朗结核菌素皮肤试验相比，QuantiFERON-TB Gold试验在伊朗HIV阳性患者中检测潜伏性结核感染的性能

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Background: There is limited data about the performance of QuantiFERON-TB Gold (QFT-G) test in detecting latent tuberculosis infection (LTBI) in our region. We intended to determine the performance of QFT-G compared to conventional tuberculin skin test (TST) in detecting LTBI in HIV-positive individuals in Iran. Methods: This study was conducted in a HIV clinic in Tehran, Iran in April 2007. A total of 50 consecutive HIV-positive patients, not currently affected with active tuberculosis (TB), were recruited; 43 (86%) were male. The mean age was 38 ± 7.2 years (21-53). All had history of Bacillus Calmette Guerin (BCG) vaccination. A TST with purified protein derivative (PPD) and whole-blood interferon-gamma release assay (IGRA) in reaction to ESAT-6 and CFP-10 antigens was performed and measured by enzyme-linked immuno-sorbent assay (ELISA). The agreement between TST and QFT-G results were analyzed using Kappa test. Results: A total of 36 (72%) patients had negative and 14 (28%) revealed positive TST. For QFT-G, 20 (40%) tested positive, 19 (38%) tested negative, and the results in 11 cases (22%) were indeterminate. A total of 14 (28%) patients had a CD4 count of P = 0.06). Although TST results were not significantly different in patients with CD4 vs. CD4 >200 (P = 0.295), association between QFT-G results and CD4 cutoff of 200 reached statistical significance (P = 0.027). Agreement Kappa coefficient between TST and QFT-G was 0.54 (Kappa = 0.54, 95% CI = 38.4-69.6, P Conclusion: Detecting LTBI in HIV-positive individuals showed moderate agreement between QFT-G and LTBI in our study. Interestingly, our findings revealed that nontuberculous mycobacteria and prior BCG vaccination have minimal influence on TST results in HIV patients in Iran.
机译：背景：关于在我们地区检测潜伏性结核感染（LTBI）的QuantiFERON-TB Gold（QFT-G）测试性能的数据有限。我们打算确定与传统结核菌素皮肤试验（TST）相比，QFT-G在伊朗HIV阳性患者中检测LTBI的性能。方法：这项研究于2007年4月在伊朗德黑兰的一家艾滋病诊所进行。共招募了50名连续的HIV阳性患者，这些患者目前未受到活动性肺结核（TB）的影响。男性为43（86％）。平均年龄为38±7.2岁（21-53）。所有人都有卡介苗芽孢杆菌（BCG）疫苗接种史。通过酶联免疫吸附测定（ELISA）进行了与ESAT-6和CFP-10抗原反应的纯化蛋白衍生物（PPD）和全血干扰素-γ释放测定（IGRA）的TST。使用Kappa测试分析了TST和QFT-G结果之间的一致性。结果：总共36例（72％）患者的TST阴性，而14例（28％）的TST阳性。对于QFT-G，20例（40％）呈阳性，19例（38％）呈阴性，11例（22％）的结果不确定。共有14位（28％）患者的CD4计数为P = 0.06）。尽管CD4和CD4> 200的患者的TST结果无显着差异（P = 0.295），但QFT-G结果与200的CD4临界值之间的相关性具有统计学意义（P = 0.027）。 TST与QFT-G之间的一致性Kappa系数为0.54（Kappa = 0.54，95％CI = 38.4-69.6，P）结论：在我们的研究中，检测HIV阳性个体中的LTBI显示QFT-G与LTBI之间具有中等一致性。研究结果表明，非结核分枝杆菌和先前的BCG疫苗接种对伊朗HIV患者的TST结果影响最小。

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