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首页> 外文期刊>Annual Research & Review in Biology >Biochemical Changes in Tissues of Wistar Albino Rats Following Exposure to Diet Incorporated with Locally Processed Fish
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Biochemical Changes in Tissues of Wistar Albino Rats Following Exposure to Diet Incorporated with Locally Processed Fish

机译：Wistar白化病大鼠的组织暴露于饮食与当地加工鱼后的生化变化

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Biochemical changes in tissues of Wistar albino rats following exposure to feed formulated with different percentage concentrations (5%, 10%, and 20%) of smoked fish after 28 days were investigated. Albino rats fed with animal feed without smoked fish served as the control. The concentrations of ascorbic acid, glutathione (GSH), total protein, albumin, globulin as well as the activities of catalase and lactate dehydrogenase (LDH) were determined/ assayed respectively, using standard methods. The results showed that there were no significant (p>0.05) differences in these parameters from rats fed with 5% smoked fish when compared to those of the control. However, there were a significant (p<0.05) decrease in the concentrations of ascorbic acid, glutathione, total protein, albumin, globulin and the activity of catalase in albino rats fed with feed formulated with 20% in contrast to increase in activity of lactate dehydrogenase in smoked fish-fed rats when compared to the control. The values obtained showed that, as the percentage of smoked fish in the formulated feed increased from 10%, the concentrations of ascorbic, glutathione and total protein (albumin and globulin) decreased. The catalase activity decreased in contrast to lactate dehydrogenase whose activity increased, indicating that the changes were concentration-dependent. The results obtained might in part indicate that the local process of smoking of fish, which involved high temperature and smoke could have induced synthesis of harmful substances probably [polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HAAs)] in the smoked fish. These harmful substances might have caused the observed changes in the concentrations and activities of these oxidative stress parameters in the rats.
机译：研究了Wistar白化病大鼠在28天后接触以不同百分比浓度（5％，10％和20％）的熏鱼配制的饲料后组织的生化变化。用不含熏鱼的动物饲料喂养的白化大鼠作为对照。使用标准方法分别测定/测定了抗坏血酸，谷胱甘肽（GSH），总蛋白，白蛋白，球蛋白的浓度以及过氧化氢酶和乳酸脱氢酶（LDH）的活性。结果表明，与对照组相比，用5％烟熏鱼喂养的大鼠的这些参数没有显着差异（p> 0.05）。然而，饲喂20％配方饲料的白化病大鼠中抗坏血酸，谷胱甘肽，总蛋白，白蛋白，球蛋白的浓度和过氧化氢酶活性显着（p <0.05）降低，而乳​​酸活性增加与对照组相比，烟熏鱼饲养的大鼠体内的脱氢酶。获得的值表明，随着配制饲料中熏制鱼的百分比从10％增加，抗坏血酸，谷胱甘肽和总蛋白（白蛋白和球蛋白）的浓度降低。与乳酸脱氢酶的活性增加相比，过氧化氢酶的活性下降，这表明该变化是浓度依赖性的。获得的结果可能部分表明，涉及高温和烟雾的鱼的局部吸烟过程可能诱导了烟熏鱼中有害物质的合成，可能是[多环芳烃（PAHs）和杂环芳香胺（HAAs）]的合成。这些有害物质可能已引起大鼠中这些氧化应激参数的浓度和活性的观察到的变化。

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