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首页> 外文期刊>Annual Research & Review in Biology >Gastrointestinal Microflora in Radiation Injury and Countermeasure
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Gastrointestinal Microflora in Radiation Injury and Countermeasure

机译：胃肠道菌群辐射损伤及对策

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摘要

Acute radiation syndrome?(ARS) is a collection of pathological conditions as a result of exposure to high amounts of?ionizing radiation (IR). Gastrointestinal (GI) system is highly sensitive to IR exposure and the symptoms include anorexia, nausea, vomiting and severe diarrhoea and can result in multiple organ failure. If remain untreated, it may result into death within 2 weeks with predominant cause being infection, dehydration and electrolyte imbalance. GI tract is inhabited by several commensal bacteria and damage to the GI system facilitates bacterial translocation to other organs due to loss in its integrity. Bacterial translocation results in conversion of commensals into opportunistic pathogens which secrete variety of lethal toxins culminating in multiple organ failure. Present review focuses on elucidating consequences of radiation exposure to GI system, the microbiota inhibiting GI and critical analysis of data from different studies done so far to counter those consequences. Using traditional therapeutics, there are no promising measures developed so far, to counter such radiation emergency to an acceptable extent. Review of existing literature urges development of innovative countermeasures and fecal transplant.
机译：急性放射综合症（ARS）是由于暴露于大量电离辐射（IR）导致的病理状况的集合。胃肠道（GI）系统对IR暴露高度敏感，症状包括厌食，恶心，呕吐和严重腹泻，并可能导致多器官功能衰竭。如果不及时治疗，可能会在2周内导致死亡，主要的原因是感染，脱水和电解质失衡。胃肠道被数种共生细菌所占据，由于其完整性的丧失，对胃肠道系统的损害促进了细菌向其他器官的移位。细菌易位导致共患病转化为机会病原体，这些病原体会分泌多种致死毒素，最终导致多器官功能衰竭。目前的审查侧重于阐明辐射暴露于胃肠道系统的后果，抑制细菌的胃肠道的微生物群以及迄今为止针对这些后果而进行的不同研究的数据的严格分析。使用传统疗法，到目前为止，还没有开发出有希望的措施来将这种辐射紧急情况抵抗到可接受的程度。对现有文献的评论敦促发展创新对策和粪便移植。

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