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首页> 外文期刊>Annals of Thoracic Medicine >The relationship between the first episode of wheezing and matrix metalloproteinases-9 and MMP-2 and tissue inhibitors of MMP-1 levels in preterm infants
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The relationship between the first episode of wheezing and matrix metalloproteinases-9 and MMP-2 and tissue inhibitors of MMP-1 levels in preterm infants

机译：早产儿喘息与基质金属蛋白酶9和MMP-2的关系与MMP-1水平的组织抑制剂之间的关系

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Aims: Matrix metalloproteinases (MMP) have been associated with neonatal lung morbidity and MMP dysregulation contributes to the pathology of chronic and acute lung disorders. Most of the previous studies were performed in the 1 st weeks of life of the preterm newborns. There are no data on the serum levels of MMP-2, MMP-9 or tissue inhibitors of matrix metalloproteinases (TIMP-1) from preterm infants recovering from lung morbidities. We aimed to compare MMP-2, MMP-9 and TIMP-1 levels in preterm and term infants hospitalized with their first episode of wheezing. Methods: We prospectively evaluated 18 preterm infants with a history of chronic lung disease, respiratory distress syndrome or oxygen therapy and 14 age- and sex-matched term infants who were admitted for a first episode of wheezing. We quantified total serum concentrations of MMP-2, MMP-9 and TIMP-1 to assess whether these serum markers levels were associated with the first episode of wheezing in infants with a history of oxygen therapy during the neonatal period. Results: Upon hospitalization, MMP-2 and TIMP-1 levels were higher in preterm infants than in term infants. In contrast, there was no significant relationship between MMP-9 levels or the MMP-9/TIMP-1 ratio between preterm and term infants. The area under the receiver operating characteristic curve for MMP-2 was 0.70 (95% confidence interval [CI] 0.51-0.89). The area under the curve for TIMP-1 was 0.78 (95% CI 0.61-0.94). MMP-9, MMP-2 and TIMP-1 levels did not correlate with gestational age, gender or severity of wheezing. Conclusion: The negative proportion of MMP-9 to TIMP-1 that we detected in term infants was not present in preterm infants. The balance of MMP-9 to TIMP-1 may have been disrupted by lung damage in the premature infants. Overproduction of MMP-2 and TIMP-1 in the serum may be associated with the pathogenesis of wheezing in preterm infants.
机译：目的：基质金属蛋白酶（MMP）已与新生儿肺部疾病相关，MMP失调导致慢性和急性肺部疾病的病理。先前的大多数研究是在早产婴儿生命的第一周中进行的。目前尚无来自肺病康复的早产儿血清MMP-2，MMP-9或基质金属蛋白酶组织抑制剂（TIMP-1）的数据。我们旨在比较第一例喘息住院的早产儿和足月儿的MMP-2，MMP-9和TIMP-1水平。方法：我们前瞻性评估了18例有慢性肺病，呼吸窘迫综合征或氧气疗法史的早产儿，以及14例年龄和性别相匹配的足月婴儿，他们均因首次喘息而入院。我们对MMP-2，MMP-9和TIMP-1的总血清浓度进行了定量，以评估这些血清标志物水平是否与新生儿期间有氧疗史的婴儿的第一次喘息有关。结果：住院后，早产儿的MMP-2和TIMP-1水平高于足月儿。相反，早产儿和足月儿之间的MMP-9水平或MMP-9 / TIMP-1比值之间没有显着关系。 MMP-2的接收器工作特性曲线下的面积为0.70（95％置信区间[CI] 0.51-0.89）。 TIMP-1的曲线下面积为0.78（95％CI 0.61-0.94）。 MMP-9，MMP-2和TIMP-1水平与胎龄，性别或喘息严重程度无关。结论：我们在足月儿中检测到的MMP-9与TIMP-1阴性比例在早产儿中不存在。早产儿的肺部损伤可能破坏了MMP-9与TIMP-1的平衡。血清中MMP-2和TIMP-1的过量产生可能与早产儿喘息的发病机理有关。

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