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首页> 外文期刊>Anthropological science: Journal of the Anthropological Society of Nippon >Genotypes of JC virus in Southeast Asia and the western Pacific: implications for human migrations from Asia to the Pacific
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Genotypes of JC virus in Southeast Asia and the western Pacific: implications for human migrations from Asia to the Pacific

机译：东南亚和西太平洋JC病毒的基因型：对人类从亚洲向太平洋迁移的影响

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JC virus (JCV) genotyping is a novel method of tracing human migrations. In the present study, we used this method to gain insights into human expansions to the western Pacific. Using the whole genome approach, four genotypes of JCV (8A, 8B, 2E, and 7A) were previously detected in the island populations of the western Pacific. Using the same approach, we detected five genotypes (B1-a, B3-a, B3-b, SC-f, and SC-x) in Filipino populations (B3-b and SC-f corresponded to 2E and 7A, respectively). From these findings, it was concluded that seven genotypes of JCV were spread in the island populations in Southeast Asia and the western Pacific (these genotypes were tentatively designated as the ocean genotypes). Three of them (B1-a, B3-a, and SC-f/7A) occurred in the Philippines but did not occur in the western Pacific; two (B3-b/2E and SC-x) occurred in the Philippines as well as in the western Pacific excluding Guam; and two (8A and 8B) occurred only in the western Pacific. These regional distribution patterns for the oceanic genotypes suggested various human migrations to the Pacific, some restricted to islands near the Asian Continent and some extended far to Remote Oceania. Furthermore, our findings were consistent with the view that the Austronesians originated in an area of Southeast Asia, including the Philippines.
机译：JC病毒（JCV）基因分型是一种追踪人类迁徙的新方法。在本研究中，我们使用这种方法来深入了解人类向西太平洋的扩张。使用全基因组方法，以前在西太平洋的岛屿种群中发现了四种JCV基因型（8A，8B，2E和7A）。使用相同的方法，我们在菲律宾人群中检测到五种基因型（B1-a，B3-a，B3-b，SC-f和SC-x）（B3-b和SC-f分别对应于2E和7A） 。根据这些发现，可以得出结论，JCV的7个基因型分布在东南亚和西太平洋的岛屿种群中（这些基因型暂定为海洋基因型）。其中三个（B1-a，B3-a和SC-f / 7A）发生在菲律宾，但未出现在西太平洋;在菲律宾以及关岛以外的西太平洋发生了两次（B3-b / 2E和SC-x）;其中两个（8A和8B）仅发生在西太平洋。这些海洋基因型的区域分布模式表明，人类向太平洋地区迁移的方式多种多样，其中有些仅限于亚洲大陆附近的岛屿，有些则已扩展到遥远的大洋洲。此外，我们的发现与南岛人起源于东南亚地区（包括菲律宾）的观点是一致的。

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