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Identifying the genes underlying quantitative traits: a rationale for the QTN programme

机译：识别定量特征的基因：QTN程序的基本原理

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The goal of identifying the genes or even nucleotides underlying quantitative and adaptive traits has been characterized as the ‘QTN programme' and has recently come under severe criticism. Part of the reason for this criticism is that much of the QTN programme has asserted that finding the genes and nucleotides for adaptive and quantitative traits is a fundamental goal, without explaining why it is such a hallowed goal. Here we outline motivations for the QTN programme that offer general insight, regardless of whether QTNs are of large or small effect, and that aid our understanding of the mechanistic dynamics of adaptive evolution. We focus on five areas: (i) vertical integration of insight across different levels of biological organization, (ii) genetic parallelism and the role of pleiotropy in shaping evolutionary dynamics, (iii) understanding the forces maintaining genetic variation in populations, (iv) distinguishing between adaptation from standing variation and new mutation, and (v) the role of genomic architecture in facilitating adaptation. We argue that rather than abandoning the QTN programme, we should refocus our efforts on topics where molecular data will be the most effective for testing hypotheses about phenotypic evolution.
机译：鉴定潜在的定量和适应性状基因或什至核苷酸的目标被称为“ QTN计划”，并且最近受到严厉批评。这种批评的部分原因是，许多QTN计划断言，为适应性和定量性状寻找基因和核苷酸是一个基本目标，而没有解释为什么这是一个神圣的目标。在此，我们概述了QTN计划的动机，无论QTN产生大还是小的影响，它都能提供一般的见识，并有助于我们了解自适应进化的机制动力学。我们专注于五个领域：（i）跨生物学组织各个层面的见解的垂直整合，（ii）遗传平行性和多效性在塑造进化动力学中的作用，（iii）了解维持种群遗传变异的力，（iv）区分适应性变化与常规变异和新突变之间的区别，以及（v）基因组架构在促进适应性变化中的作用。我们认为，与其放弃QTN计划，不如将精力重新集中在分子数据将最有效地检验关于表型进化的假设的话题上。

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