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首页> 外文期刊>Anuario de Psicologia Juridica >Production of nanostructured molecular liquids by supercritical CO 2 processing
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Production of nanostructured molecular liquids by supercritical CO 2 processing

机译：通过超临界CO 2 处理生产纳米结构分子液体

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Stable molecular clusters of ibuprofen and naproxen were prepared in dry ice, by supersonic jet expansion of their supercritical CO 2 drug formulations into a liquid nitrogen cooled collection vessel, with up to 80% yield. Mixing the “dry ice” in water, resulted in the solubilization of the clusters and in the case of ibuprofen, we were able to create solutions, with concentrations of up to 6mg/ml, a 300-fold increase over previously reported values. Drop casting and ambient drying of these solutions on silicon substrate resulted in a stable, viscous liquid film, referred to as nanostructured molecular liquids. These liquids exhibited a highly aligned, fine (self-assembled) super lattice features. In vitro cancer cell viability studies of these formulations exhibited similar cytotoxicity to that of the original raw materials, thus retaining their original potency. Besides its scientific importance, this invention is expected to open up new drug delivery platforms. Graphical abstract The graphical image shows the custom desigend, constant (P,T) RESS process to produce moelcular clusters in high yield and the generation of moelcular liquids as thin films. Display Omitted Highlights ? Stable molecular clusters of Naproxen and Ibuprofen. ? Ibuprofen water solubility increased by 300X. ? Non-thermodynamic, “kinetically locked in” structures. ? Room temperature liquid-like property. ? Cytotoxicity of molecular clusters comparable to standard powders.
机译：在干冰中，通过超音速将超临界CO 2药物制剂超声喷射到液氮冷却的收集容器中，制得布洛芬和萘普生的稳定分子簇。在水中混入“干冰”，使团簇增溶，在布洛芬的情况下，我们能够制备浓度高达6mg / ml的溶液，是以前报道的值的300倍。这些溶液在硅基板上的滴铸和环境干燥产生了稳定的粘性液体薄膜，称为纳米结构分子液体。这些液体表现出高度对准的，精细的（自组装）超晶格特征。这些制剂的体外癌细胞活力研究显示出与原始原料相似的细胞毒性，因此保留了它们的原始效能。除了其科学重要性之外，预期本发明将开拓新的药物递送平台。图形摘要图形图像显示了定制的设计，恒定（P，T）RESS过程，可高产量地生产分子簇，并生成薄膜的分子液体。显示省略的突出显示？萘普生和布洛芬的稳定分子簇。 ？布洛芬的水溶性增加了300倍。 ？非热力学“动态锁定”结构。 ？常温下呈液体状。 ？分子簇的细胞毒性可与标准粉末相比。

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