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Physico-chemical analysis of herbally prepared silver nanoparticles and its potential as a drug bioenhancer

机译:草药制备的银纳米颗粒的理化分析及其作为药物生物增强剂的潜力

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In order to exhibit its potential benefits, a drug must cross the epithelial barrier of the intestinal mucosa for transportation into systemic circulation. Several approaches have been proposed to overcome these barriers, including enhancing drug potency through the use of bioenhancers. The concurrent application of bio-enhancers with pharmaceuticals is not a new development, but has been used for thousands of years. The traditional medical system used in India (Ayurveda) has utilized formulations including metal powders (bhasma) to treat a large number of health issues. However, without the support of modern science, these methodologies are largely ignored throughout the western world. Recent studies have begun to examine not only structure and compositional studies but also studies targeted at understanding the mode of action of these materials. Preliminary studies carried out below indicate the potential of these powders to act as non-reactive bio-enhancer for drug delivery. Graphical abstract Display Omitted.
机译:为了展现其潜在的益处,药物必须穿过肠粘膜的上皮屏障才能转运到全身循环中。已经提出了几种克服这些障碍的方法,包括通过使用生物增强剂来增强药物效力。将生物增强剂与药物同时使用并不是什么新进展,但已经使用了数千年。印度(Ayurveda)使用的传统医疗系统已利用包括金属粉末(bhasma)在内的配方来治疗大量健康问题。但是,在没有现代科学支持的情况下,整个西方世界都忽略了这些方法。最近的研究已经开始不仅检查结构和组成研究,而且还研究旨在了解这些材料的作用方式的研究。下面进行的初步研究表明,这些粉末有可能作为非反应性生物增强剂用于药物递送。图形抽象显示被忽略。

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