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首页> 外文期刊>Anuario de Psicologia Juridica >Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150?MeV proton beam
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Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150?MeV proton beam

机译：高Z金属纳米粒子对150？MeV质子束辐照对人结肠癌细胞（HCT116）的放射增敏作用和ROS的产生。

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Radiosensitization effects caused by high atomic number (Z) metallic nanoparticles have been extensively explored with a wide range of X-ray based radiotherapy beams that seem to provide intriguing results for potential clinical applications. In this study, the radiobiological consequences of gold nanoparticles (AuNPs), superparamagnetic iron oxide nanoparticles (SPIONs), Platinum Nanodendrites (PtNDs) and Bismuth Oxide Nanorods (BiNRs) on Human Colon Carcinoma cells (HCT 116) irradiated with 150?MeV proton beams were investigated. Cell survival and reactive oxygen species (ROS) generation were measured. BiNRs demonstrates the highest sensitization enhancement ratio (SER) of 4.93 followed by PtNDs with SER value of 3.08. Meanwhile, AuNPs and SPIONs depict SER values around 2.64 and 1.95 respectively. The ROS generation corresponded to the level of radiosensitization with the highest ROS obtained for BiNRs and followed by PtNDs, AuNPs and SPIONs. In conclusion, high Z nanoparticles possess the potential to be clinically applied in proton beam therapy.
机译：由高原子序数（Z）金属纳米颗粒引起的放射增敏作用已被广泛的基于X射线的放射治疗束广泛地探索，这似乎为潜在的临床应用提供了有趣的结果。在这项研究中，金纳米颗粒（AuNPs），超顺磁性氧化铁纳米颗粒（SPIONs），铂纳米树突（PtNDs）和氧化铋纳米棒（BiNRs）对150？MeV质子束辐照的人结肠癌细胞（HCT 116）的放射生物学后果。被调查了。测量细胞存活和活性氧（ROS）生成。 BiNRs表现出最高的增感增强比（SER）为4.93，其次是PtNDs，SER值为3.08。同时，AuNP和SPION分别表示SER值在2.64和1.95附近。 ROS的生成对应于放射敏感性水平，其中BiNRs的ROS最高，其次是PtNDs，AuNPs和SPIONs。总之，高Z纳米粒子具有在质子束治疗中临床应用的潜力。

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