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首页> 外文期刊>Antibiotics >Role of Old Antibiotics in the Era of Antibiotic Resistance. Highlighted Nitrofurantoin for the Treatment of Lower Urinary Tract Infections
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Role of Old Antibiotics in the Era of Antibiotic Resistance. Highlighted Nitrofurantoin for the Treatment of Lower Urinary Tract Infections

机译：旧抗生素在抗生素耐药性时代的作用。突出的呋喃妥因用于治疗下尿路感染

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Bacterial infections caused by antibiotic-resistant isolates have become a major health problem in recent years, since they are very difficult to treat, leading to an increase in morbidity and mortality. Nitrofurantoin is a broad-spectrum bactericidal antibiotic that, through a complex mode of action which is not completely understood, affects both Gram-negative and Gram-positive bacteria. Nitrofurantoin has been used successfully for a long time for the prophylaxis and treatment of acute lower urinary tract infections in adults, children and pregnant women, but the increased emergence of antibiotic resistance has made nitrofurantoin a suitable candidate for the treatment of infections caused by multidrug-resistant pathogens. Here, we review the mechanism of action, antimicrobial spectrum, pharmacology and safety profile of nitrofurantoin. We also investigate the therapeutic use of nitrofurantoin, including recent data which highlight its role in the management of community urinary tract infection, especially in cases of multidrug-resistant isolates, in which oral active antimicrobials are limited resources nowadays.
机译：近年来，由抗生素抗性分离株引起的细菌感染已成为主要的健康问题，因为它们很难治疗，从而导致发病率和死亡率增加。呋喃妥因是一种广谱杀菌抗生素，其通过复杂的作用方式（尚未完全了解）会影响革兰氏阴性菌和革兰氏阳性菌。呋喃妥因已成功用于预防和治疗成人，儿童和孕妇的急性下尿路感染，但是由于抗生素耐药性的增加，使得呋喃妥因成为治疗多种药物引起的感染的合适人选抗性病原体。在这里，我们审查了呋喃妥因的作用机理，抗菌谱，药理作用和安全性。我们还研究了呋喃妥因的治疗用途，包括最近的数据，这些数据突显了呋喃妥因在社区尿路感染的管理中的作用，尤其是在对多药耐药的分离株的情况下，其中口服活性抗微生物剂是当今的有限资源。

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