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首页> 外文期刊>Antibiotics >Adult and Pediatric Intra-Institutional Trends of Ciprofloxacin Susceptibility in E. coli Positive Urinary Cultures
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Adult and Pediatric Intra-Institutional Trends of Ciprofloxacin Susceptibility in E. coli Positive Urinary Cultures

机译：大肠杆菌阳性尿培养中环丙沙星敏感性的成人和儿童机构内趋势

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摘要

Antimicrobial drug resistance in treatment of urinary tract infection (UTI) continues to rise worldwide. To examine contributions of physician prescribing patterns to fluoroquinolone (ciprofloxacin, CP) resistance, we examined Escherichia coli (E. coli) resistance patterns in urinary cultures. Since CP usage is limited in children, we compared CP resistance trends in adults and children to those of more commonly used trimethoprim-sulfamethoxazole (TMP-SMX) and nitrofurantoin (NF). Our data show that although the general pediatric population has lower resistance to ciprofloxacin, resistance levels are rising with increased usage. While NF susceptibility is historically stable, TMP-SMX resistance is slightly higher in children compared to adults. In both adults and children, antimicrobial resistance patterns vary according to clinical practice site, with ambulatory urology patients showing the highest resistance. This suggests that physician’s prescribing patterns contribute to antimicrobial resistance.
机译：在世界范围内，治疗尿路感染（UTI）的抗菌药物耐药性持续上升。为了检查医师处方模式对氟喹诺酮（环丙沙星，CP）耐药性的贡献，我们检查了尿培养物中大肠杆菌（E. coli）耐药性模式。由于儿童中CP的使用受到限制，因此我们将成人和儿童中CP的抵抗趋势与更常用的甲氧苄啶-磺胺甲基恶唑（TMP-SMX）和呋喃妥因（NF）进行了比较。我们的数据显示，尽管一般儿科人群对环丙沙星的抵抗力较低，但随着使用量的增加，抵抗力水平也在上升。尽管NF敏感性在历史上是稳定的，但与成人相比，儿童的TMP-SMX耐药性略高。在成人和儿童中，抗菌素耐药性模式均根据临床实践部位而有所不同，非卧床泌尿科患者表现出最高的耐药性。这表明医师的处方模式有助于抗菌素耐药性。

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