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首页> 外文期刊>Antibiotics >Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection
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Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection

机译：强力霉素和替吉环素：两种与梭状芽胞杆菌难感染性相关性低的友好药物

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Clostridium difficile infection (CDI) is known to be associated with prior exposure to many classes of antibiotics. Standard therapy for CDI (i.e., metronidazole and vancomycin) is associated with high recurrence rates. Although tetracycline derivatives such as tetracycline, doxycycline or tigecycline are not the standard therapeutic choices for CDI, they may serve as an alternative or a component of combination therapy. Previous tetracycline or doxycycline usage had been shown to have less association with CDI development. Tigecycline, a broad-spectrum glycylcycline with potency against many gram-positive or gram-negative pathogens, had been successfully used to treat severe or refractory CDI. The in vitro susceptibility of C. difficile clinical isolates to tigecycline in many studies showed low minimal inhibitory concentrations. Tigecycline can suppress in vitro toxin production in both historical and hypervirulent C. difficile strains and reduce spore production in a dose-dependent manner. Tetracycline compounds such as doxycycline, minocycline, and tigecycline possess anti-inflammatory properties that are independent of their antibiotic activity and may contribute to their therapeutic effect for CDI. Although clinical data are limited, doxycycline is less likely to induce CDI, and tigecycline can be considered one of the therapeutic choices for severe or refractory CDI.
机译：已知艰难梭菌感染（CDI）与先前接触多种抗生素有关。 CDI的标准疗法（即甲硝唑和万古霉素）与高复发率相关。尽管四环素衍生物（例如四环素，强力霉素或替加环素）不是CDI的标准治疗选择，但它们可以作为替代疗法或组合疗法的组成部分。先前的四环素或强力霉素的使用已被证明与CDI的发展联系较少。 Tigecycline是一种广谱的甘氨酰环素，对许多革兰氏阳性或革兰氏阴性病原体均具有效力，已成功用于治疗严重或难治性CDI。在许多研究中，艰难梭菌临床分离株对替加环素的体外敏感性显示最低的最低抑制浓度。 Tigecycline可以抑制历史性和高毒性艰难梭菌菌株的体外毒素产生，并以剂量​​依赖性方式降低孢子产生。四环素化合物（例如强力霉素，米诺环素和替加环素）具有抗炎特性，这些特性与它们的抗生素活性无关，并且可能有助于其对CDI的治疗作用。尽管临床数据有限，但强力霉素诱导CDI的可能性较小，替加环素可被视为重度或难治性CDI的治疗选择之一。

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