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Sub-Optimal Treatment of Bacterial Biofilms

机译：细菌生物膜的次优处理

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Bacterial biofilm is an emerging clinical problem recognized in the treatment of infectious diseases within the last two decades. The appearance of microbial biofilm in clinical settings is steadily increasing due to several reasons including the increased use of quality of life-improving artificial devices. In contrast to infections caused by planktonic bacteria that respond relatively well to standard antibiotic therapy, biofilm-forming bacteria tend to cause chronic infections whereby infections persist despite seemingly adequate antibiotic therapy. This review briefly describes the responses of biofilm matrix components and biofilm-associated bacteria towards sub-lethal concentrations of antimicrobial agents, which may include the generation of genetic and phenotypic variabilities. Clinical implications of bacterial biofilms in relation to antibiotic treatments are also discussed.
机译：细菌生物膜是最近二十年来在治疗传染病中公认的新兴临床问题。由于包括增加使用改善生活质量的人造装置的质量在内的若干原因，微生物生物膜在临床环境中的出现稳步增加。与由浮游细菌引起的对标准抗生素治疗反应相对较好的感染相反，形成生物膜的细菌往往会引起慢性感染，尽管看似适当的抗生素治疗，但感染仍持续存在。这篇综述简要描述了生物膜基质成分和生物膜相关细菌对亚致死浓度的抗菌剂的反应，这可能包括遗传和表型变异的产生。还讨论了与抗生素治疗有关的细菌生物膜的临床意义。

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