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首页> 外文期刊>Advances in hematology >Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma
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Clinical, Molecular, and Environmental Risk Factors for Hodgkin Lymphoma

机译：霍奇金淋巴瘤的临床，分子和环境危险因素

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Epidemiological studies suggest unique occurrence patterns of Hodgkin lymphoma (HL) worldwide. In most Western countries there is a clear bimodal age distribution with an early peak in young adults followed by a second peak in older adults, particularly among males. In the Middle East and Asia, HL is more common in early childhood. There also are marked racial differences in the presentations of HL and HL subtypes, and particular single nucleotide polymorphisms (SNPs) have been identified as etiological factors suggesting that gene-gene and gene-environment interactions are involved. Personal health choices such as exercise and smoking may modify an individual's chances of developing HL. Numerous studies highlight the impact that exposure to Epstein-Barr virus and other environmental factors have on HL risk. Understanding the relative importance of each of these findings and their links to HL development and survival will help clinical researchers expand curative therapies and create preventative strategies for HL.
机译：流行病学研究表明，全世界霍奇金淋巴瘤（HL）的独特发生方式。在大多数西方国家中，双峰年龄分布明显，青年人早高峰，而老年人，尤其是男性，则出现第二高峰。在中东和亚洲，HL在幼儿期更为常见。在HL和HL亚型的表现形式上也存在明显的种族差异，并且特定的单核苷酸多态性（SNP）已被确定为病因，表明基因与基因和基因与环境之间的相互作用。运动和吸烟等个人健康选择可能会改变个人患HL的机会。大量研究强调了暴露于爱泼斯坦-巴尔病毒和其他环境因素对HL风险的影响。了解这些发现各自的相对重要性及其与HL的发展和生存的联系将有助于临床研究人员扩大治愈性疗法并制定HL的预防策略。

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