...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Applied Nanoscience >Novel isotretinoin microemulsion-based gel for targeted topical therapy of acne: formulation consideration, skin retention and skin irritation studies
【24h】

Novel isotretinoin microemulsion-based gel for targeted topical therapy of acne: formulation consideration, skin retention and skin irritation studies

机译：基于异维A酸微乳液的新型凝胶剂可用于痤疮的靶向局部治疗：配方考虑，皮肤滞留和皮肤刺激性研究

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Isotretinoin was formulated in novel microemulsion-based gel formulation with the aim of improving its solubility, skin tolerability, therapeutic efficacy, skin-targeting efficiency and patient compliance. Microemulsion was formulated by the spontaneous microemulsification method using 8?% isopropyl myristate, 24?% Labrasol, 8?% plurol oleique and 60?% water as an external phase. All plain and isotretinoin-loaded microemulsions were clear and showed physicochemical parameters for the desired topical delivery and stability. The permeation profiles of isotretinoin through rat skin from selected microemulsion formulation followed zero-order kinetics. Microemulsion-based gel was prepared by incorporating Carbopol?971 in optimized microemulsion formulation having suitable skin permeation rate and skin uptake. Microemulsion-based gel showed desired physicochemical parameters and demonstrated advantage over marketed formulation in improving the skin tolerability of isotretinoin, indicating its potential in improving topical delivery of isotretinoin. The developed microemulsion-based gel may be a potential drug delivery vehicle for targeted topical delivery of isotretinoin in the treatment of acne.
机译：异维A酸以新型微乳液凝胶配方配制，旨在提高其溶解度，皮肤耐受性，治疗功效，皮肤靶向效率和患者依从性。通过自发微乳化法，使用8％的肉豆蔻酸异丙酯，24％的Labrasol，8％的油醇和60％的水作为外相，配制微乳液。所有普通的和异维A酸装载的微乳剂都是透明的，并显示出所需的局部递送和稳定性的理化参数。异维A酸通过所选微乳剂配方通过大鼠皮肤的渗透曲线遵循零级动力学。通过将Carbopol α 971掺入具有合适的皮肤渗透速率和皮肤吸收能力的优化的微乳液制剂中来制备基于微乳液的凝胶。基于微乳液的凝胶在改善异维A酸的皮肤耐受性方面显示出所需的理化参数，并显示出优于市售制剂的优势，表明其在改善异维A酸的局部递送中具有潜力。开发的基于微乳液的凝胶可能是潜在的药物输送媒介，可用于治疗痤疮中异维A酸的靶向局部输送。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号