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Real-time cellular and molecular dynamics of bi-metallic self-therapeutic nanoparticle in cancer cells

机译：癌细胞中双金属自我治疗纳米颗粒的实时细胞和分子动力学

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Since last decades various kinds of nanoparticles have been functionalized to improve their biomedical applications. However, the biological effect of un-modifiedon-functionalized bi-metallic magnetic nanoparticles remains under investigated. Herein we demonstrate a multifaceted non-functionalized bi-metallic inorganic Gd-SPIO nanoparticle which passes dual high MRI contrast and can kill the cancer cells through several mechanisms. The results of the present study demonstrate that Gd-SPIO nanoparticles have potential to induce cancer cell death by production of reactive oxygen species and apoptotic events. Furthermore, Gd-SPIO nanoparticles also enhance the expression levels of miRNA-199a and miRNA-181a-7p which results in decreased levels of cancer markers such as C-met, TGF-β and hURP. One very interesting finding of this study reveals side scatter-based real-time analysis of nanoparticle uptake in cancer cells using flow cytometry analysis. In conclusion, this study paves a way for future investigation of un-modified inorganic nanoparticles to purport enhanced therapeutic effect in combination with potential anti-tumor drugs/molecules in cancer cells.
机译：自从过去的几十年以来，已经对各种类型的纳米颗粒进行了功能化以改善其生物医学应用。然而，未修饰/未官能化的双金属磁性纳米颗粒的生物学效应仍在研究中。在本文中，我们展示了一种多面的非功能化双金属无机Gd-SPIO纳米颗粒，该颗粒通过MRI双重高对比度，可以通过多种机制杀死癌细胞。本研究的结果表明，Gd-SPIO纳米颗粒具有通过产生活性氧和凋亡事件来诱导癌细胞死亡的潜力。此外，Gd-SPIO纳米颗粒还增强了miRNA-199a和miRNA-181a-7p的表达水平，这导致癌症标记物（例如C-met，TGF-β和hURP）水平降低。这项研究的一个非常有趣的发现揭示了使用流式细胞术分析基于侧面散射的癌细胞中纳米颗粒摄取的实时分析。总而言之，这项研究为未修饰的无机纳米颗粒与潜在的抗肿瘤药物/分子在癌细胞中的组合治疗作用的进一步研究铺平了道路。

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