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首页> 外文期刊>Applied Nanoscience >Tolnaftate–graphene composite-loaded nanoengineered electrospun scaffolds as efficient therapeutic dressing material for regimen of dermatomycosis
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Tolnaftate–graphene composite-loaded nanoengineered electrospun scaffolds as efficient therapeutic dressing material for regimen of dermatomycosis

机译：托拉夫特-石墨烯复合负载的纳米工程电纺丝支架是皮肤癣菌病治疗方案的有效治疗敷料

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Graphene “The novel carbon nano-trope” tailors auspicious platform for designing antimicrobial regimen by virtue of its conspicuous molecular interaction with the microorganism. In this work, Tolnaftate (Tf), an antifungal drug, was mingled with Graphene nanoplatelets (Gn) to develop composite (Tf–Gn) via the wet chemical route, embedded in a biocompatible polymeric blend of Eudragit RL100/Eudragit RS100 (EuRL100/EuRS100) and subjected to electrospinning to obtain nonwoven nanoengineered scaffolds (nanofibers) for enhanced anti-dermatophytic virtue. Pursuing cluster of optimization experiments, 20% w/v EuRL100/EuRS 100 was found to be adequate for formation of smooth, defect-free, and regular fibers. Field emission electron microscopy (FESEM) acknowledged zestfully fabrication of smooth, shiny, nano-range, and mesh-like architecture, comprising distinct pockets within their structure. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimeter (DSC) conceded formation of the composite Tf–Gn, its physical compatibility with polymers, and improved thermal behavior. Exceptional swelling capacity, significant hydrophilicity, and immense drug entrapment efficiency were obtained of nanofibers fabricated from 3:1 ratio of EuRL100/EuRS100 polymers blend owing to relatively higher permeability which gratified essential benchmark for fabrication of nanofibrous scaffold to alleviate fungal infections caused by dermatophytes. In vitro drug release interpreted controlled liberation of Tf in dissolution media, following Korsmeyer–Peppas model kinetics, and suggested a diffusion-based mechanism. Microdilution broth method was performed for in vitro antifungal efficacy against extremely devastating dermatophytes, i.e., anthropophilic Trichophyton rubrum and zoophilic Microsporum canis, exhibited preeminent growth inhibition against T.rubrum and scanty for M.canis. Findings revealed the superior antifungal activity of Tf–Gn-loaded nanofibers as compared to Tf-loaded nanofibers and recommended potential dressing materials for an effective regimen of dermatomycosis.
机译：石墨烯“新型碳纳米管”凭借其与微生物的显着分子相互作用，为设计抗菌方案设计了一个吉祥平台。在这项工作中，抗真菌药Tolnaftate（Tf）与石墨烯纳米血小板（Gn）混合，通过湿化学途径开发复合物（Tf–Gn），并嵌入生物相容的Eudragit RL100 / Eudragit RS100（EuRL100 / EuRS100）并进行静电纺丝，以获得非织造的纳米工程支架（纳米纤维），以增强抗皮肤癣菌的功效。进行一系列的优化实验，发现20％w / v EuRL100 / EuRS 100足以形成光滑，无缺陷和规则的纤维。场发射电子显微镜（FESEM）肯定是对光滑，有光泽，纳米范围和网状结构的热情制造，该结构在其结构中包含明显的凹穴。傅里叶变换红外光谱（FTIR）和差示扫描量热仪（DSC）承认了复合Tf-Gn的形成，与聚合物的物理相容性以及改善的热行为。由比例为3：1的EuRL100 / EuRS100聚合物共混物制成的纳米纤维，由于具有相对较高的渗透性，因此具有出色的溶胀能力，显着的亲水性和极大的药物截留效率，这满足了制备纳米纤维支架以减轻由皮肤癣菌引起的真菌感染所必需的基准。遵循Korsmeyer-Peppas模型动力学，体外药物释放解释了Tf在溶出介质中的受控释放，并提出了基于扩散的机制。进行了微稀释肉汤法，以针对极具破坏性的皮肤癣菌即嗜人毛癣菌和嗜生性小孢子菌进行体外抗真菌药效，显示出对丁香支原体的显着生长抑制作用，而犬念珠菌则很少。研究结果表明，与含Tf的纳米纤维相比，含Tf-Gn的纳米纤维具有更好的抗真菌活性，并推荐了用于皮肤癣菌病有效疗法的潜在敷料。

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