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首页> 外文期刊>Applied Nanoscience >Synthesis and characterization of protocatechuic acid-loaded gadolinium-layered double hydroxide and gold nanocomposite for theranostic application
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Synthesis and characterization of protocatechuic acid-loaded gadolinium-layered double hydroxide and gold nanocomposite for theranostic application

机译：负载原儿茶酸的-层双氢氧化物和金纳米复合材料的合成及表征

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摘要

A theranostic nanocomposite was developed using anticancer agent, protocatechuic acid (PA) and magnetic resonance imaging (MRI) contrast agent gadolinium nitrate (Gd) for simultaneous delivery using layered double hydroxide (LDH) as the delivery agent. Gold nanoparticles (AuNPs) were adsorbed on the surface of the LDH, which served as a complementary contrast agent. Based on the concept of supramolecular chemistry (SPC) and multimodal delivery system (MDS), the PA and Gd guests were first intercalated into the LDH host and subsequently AuNPs were surface adsorbed as the third guest. The nanohybrid developed was named MAPGAu. The MAPGAu was exposed to various characterizations at different stages of synthesis, starting with XRD analysis, which was used to confirm the intercalation episode and surface adsorption of the guest molecules. Consequently, FESEM, Hi-TEM, XRD, ICP-OES, CHNS, FTIR and UV–Vis analyses were done on the nanohybrids. The result of XRD analysis indicated successful intercalation of the Gd and PA as well the adsorption of AuNPs. The UV–Vis release study showed 90% of the intercalated drug was released at pH 4.8, which is the pH of the cancer cells. The FESEM and TEM micrographs obtained equally confirmed the formation of MAGPAu nanocomposite, with AuNPs conspicuously deposited on the LDH surface. The cytotoxicity study of the nanohybrid also showed insignificant toxicity to normal cell lines and significant toxicity to cancer cell lines. The developed MAGPAu nanocomposite has shown prospects for future theranostic cancer treatment.
机译：使用抗癌剂，原儿茶酸（PA）和磁共振成像（MRI）造影剂硝酸g（Gd）开发了一种治疗型纳米复合材料，用于同时使用层状双氢氧化物（LDH）作为输送剂。金纳米颗粒（AuNPs）吸附在LDH的表面上，LDH用作补充造影剂。基于超分子化学（SPC）和多峰传递系统（MDS）的概念，首先将PA和Gd客体插入LDH主体，然后将AuNPs作为第三客体表面吸附。所开发的纳米杂交体名为MAPGAu。从XRD分析开始，MAPGAu在合成的不同阶段经历了各种表征，该分析用于确认客体分子的插层现象和表面吸附。因此，对纳米杂化物进行了FESEM，Hi-TEM，XRD，ICP-OES，CHNS，FTIR和UV-Vis分析。 XRD分析的结果表明，Gd和PA的成功嵌入以及AuNPs的吸附。 UV-Vis释放研究表明90％的嵌入药物在pH 4.8（即癌细胞的pH）下释放。获得的FESEM和TEM显微照片同样证实了MAGPAu纳米复合材料的形成，其中AuNPs明显沉积在LDH表面。纳米杂交体的细胞毒性研究还显示出对正常细胞系的毒性微不足道，而对癌细胞系的显着毒性。研制的MAGPAu纳米复合材料显示了未来治疗性肿瘤治疗的前景。

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