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CREB: A Key Regulator of Normal and Neoplastic Hematopoiesis

机译：CREB：正常和肿瘤性造血功能的关键调节器

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The cAMP response element-binding protein (CREB) is a nuclear transcription factor downstream of cell surface receptors and mitogens that is critical for normal and neoplastic hematopoiesis. Previous work from our laboratory demonstrated that a majority of patients with acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) overexpress CREB in the bone marrow. To understand the role of CREB in leukemogenesis, we examined the biological effect of CREB overexpression on primary leukemia cells, leukemia cell lines, and CREB overexpressing transgenic mice. Our results demonstrated that CREB overexpression leads to an increase in cellular proliferation and survival. Furthermore, CREB transgenic mice develop a myeloproliferative disorder with aberrant myelopoiesis in both the bone marrow and spleen. Additional research from other groups has shown that the expression of the cAMP early inducible repressor (ICER), a CREB repressor, is also deregulated in leukemias. And, miR-34b, a microRNA that negative regulates CREB expression, is expressed at lower levels in myeloid leukemia cell lines compared to that of healthy bone marrow. Taken together, these data suggest that CREB plays a role in cellular transformation. The data also suggest that CREB-specific signaling pathways could possibly serve as potential targets for therapeutic intervention.
机译：cAMP反应元件结合蛋白（CREB）是细胞表面受体和有丝分裂原下游的核转录因子，对于正常和肿瘤性造血至关重要。我们实验室的先前工作表明，大多数急性髓细胞性白血病（AML）和急性淋巴性白血病（ALL）患者在骨髓中过度表达CREB。为了了解CREB在白血病发生中的作用，我们检查了CREB过表达对原代白血病细胞，白血病细胞系和CREB过表达转基因小鼠的生物学作用。我们的结果表明，CREB的过表达导致细胞增殖和存活的增加。此外，CREB转基因小鼠在骨髓和脾脏均发生骨髓增生异常的骨髓增生性疾病。其他小组的其他研究表明，白血病中cAMP早期诱导型阻遏物（ICER）（一种CREB阻遏物）的表达也被下调。而且，与健康骨髓相比，miR-34b（一种负调节CREB表达的微RNA）在髓样白血病细胞系中的表达水平较低。综上所述，这些数据表明CREB在细胞转化中起作用。数据还表明，CREB特异性信号传导途径可能会成为治疗干预的潜在靶标。

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