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Development and Characterization of New Species Cross-Reactive Anti-Sialoadhesin Monoclonal Antibodies

机译：新型交叉反应抗唾液酸粘蛋白单克隆抗体的开发与表征

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Sialoadhesin (Sn) is a surface receptor expressed on a subset of macrophages in steady state conditions. During inflammation and diseases, Sn is highly upregulated on macrophages and blood monocytes. Therefore, therapies using monoclonal antibodies (mAbs) to target Sn-positive (Sn + ) cells are a potential strategy for targeted treatment. It has been shown that Sn internalizes after binding with a mAb, though it is not clear whether this is species-specific. In this study, new Sn-specific mAbs were developed and analyzed for cross-reactivity between species. In addition, the newly developed mAbs were compared to mAbs used in previous research for their epitope recognition and other Sn-specific characteristics. Both species-specific and cross-reactive antibodies could be identified. Furthermore, sialic acid-binding of red blood cells (RBC) could be inhibited with mAbs recognizing different epitopes and all mAb showed internalization of Sn. The newly developed mAbs can be used as novel tools for Sn research and further analysis of Sn internalization in different species.
机译：Sialoadhesin（Sn）是在稳态条件下在巨噬细胞的一部分上表达的表面受体。在炎症和疾病期间，Sn在巨噬细胞和血液单核细胞上高度上调。因此，使用单克隆抗体（mAbs）靶向Sn阳性（Sn +）细胞的疗法是靶向治疗的潜在策略。已经表明，Sn在与mAb结合后会内在化，尽管尚不清楚它是否具有物种特异性。在这项研究中，开发了新的Sn特异性mAb并分析了物种之间的交叉反应性。此外，将新开发的mAbs与先前研究中使用的mAbs进行了表位识别和其他Sn特异性特征的比较。物种特异性抗体和交叉反应性抗体均可被鉴定。此外，可以通过识别不同表位的mAb抑制红细胞（RBC）的唾液酸结合，并且所有mAb均显示Sn的内在化。新开发的mAb可用作研究Sn和进一步分析不同物种中Sn内在化的新颖工具。

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