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首页> 外文期刊>Antioxidants >A Review of Oxidative Stress and Urinary Dysfunction Caused by Bladder Outlet Obstruction and Treatments Using Antioxidants
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A Review of Oxidative Stress and Urinary Dysfunction Caused by Bladder Outlet Obstruction and Treatments Using Antioxidants

机译：膀胱出口梗阻引起的氧化应激和尿功能异常的研究进展及抗氧化剂的治疗

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Urinary dysfunction is a common pathological condition that can significantly decrease the quality of life. Bladder outlet obstruction (BOO) is a major cause of urinary dysfunction, and various lower urinary tract diseases including benign prostatic hyperplasia and urethral stricture disease cause BOO. According to the results of a variety of animal experiments on partial BOO (PBOO), there is a general agreement that ischemic conditions and repeated ischemia/reperfusion of the bladder are closely associated with BOO-induced bladder damage, and that increased oxidative stress by ischemia/reperfusion plays a crucial role in the pathological mechanisms underlying urinary dysfunction. Changes in biomarkers of oxidative stress in PBOO animal models support this association between oxidative stress and urinary dysfunction. Oxidative stress is defined as an imbalance between the production of pro-oxidants, such as free radicals and reactive species, and their elimination through protective mechanisms of antioxidants. Therefore, organizing the knowledge on the state of oxidative stress, changes in biomarkers, and biological roles of antioxidants in systemic and bladder tissues is essential to understand the detailed pathological characteristics of the urinary dysfunction caused by PBOO. Furthermore, information on drugs and supplements that have antioxidant effects is important for defining treatment strategies for urinary dysfunction with PBOO. In this review, we paid special attention to the following three issues; (1) changes in oxidative stress, including its biomarkers, (2) antioxidant status, and (3) previous reports on treatment strategies involving agents with antioxidative activity for urinary dysfunction caused by BOO. In particular, we provide systematic information on the detailed mechanisms underlying the antioxidative effects of agents used to treat PBOO. In addition, we show present research issues and research limitations, as well as suggest possible future antioxidant treatment strategies for patients with PBOO.
机译：尿路功能障碍是一种常见的病理性疾病，会显着降低生活质量。膀胱出口梗阻（BOO）是引起泌尿功能障碍的主要原因，而各种下尿路疾病（包括良性前列腺增生和尿道狭窄疾病）也是引起BOO的原因。根据对部分BOO（PBOO）进行的各种动物实验的结果，普遍同意，缺血性疾病和反复进行的膀胱缺血/再灌注与BOO诱导的膀胱损伤密切相关，并且缺血引起的氧化应激增加/再灌注在尿路功能障碍的病理机制中起着至关重要的作用。 PBOO动物模型中氧化应激生物标志物的变化支持氧化应激与尿功能障碍之间的这种联系。氧化应激定义为促氧化剂（例如自由基和反应性物种）的产生与通过抗氧化剂的保护机制消除的不平衡。因此，组织有关氧化应激状态，生物标志物变化以及抗氧化剂在全身和膀胱组织中的生物学作用的知识对于理解PBOO引起的泌尿功能障碍的详细病理特征至关重要。此外，有关具有抗氧化作用的药物和补充剂的信息对于确定PBOO引起的泌尿功能障碍的治疗策略也很重要。在这次审查中，我们特别注意以下三个问题： （1）氧化应激的变化，包括其生物标志物，（2）抗氧化剂状态，以及（3）以前有关治疗策略的报道，这些策略涉及对由BOO引起的泌尿功能障碍具有抗氧化活性的药物。特别是，我们提供了有关用于治疗PBOO的试剂的抗氧化作用的详细机制的系统信息。此外，我们显示了当前的研究问题和研究局限性，并建议了PBOO患者未来可能的抗氧化剂治疗策略。

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