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首页> 外文期刊>Advancements in Life Sciences >Green synthesis and antibacterial activities of silver nanoparticles against Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa and Staphylococcus aureus
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Green synthesis and antibacterial activities of silver nanoparticles against Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa and Staphylococcus aureus

机译：银纳米颗粒对大肠杆菌，伤寒沙门氏菌，铜绿假单胞菌和金黄色葡萄球菌的绿色合成和抑菌活性

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Background: Over the last two decades infectious agents have become more dangerous, most especially in developing countries, due to their ability to develop resistance against orthodox medicines. Many in these countries are suffering from the debilitating effects of these pathogens without any remedies in sight. The recent researches in nanoparticles derived from medicinal plants seem to be yielding positive results. Methods: We carried out synthesis of silver nanoparticles from AgNO3 and using Hyaluronic acid as a stabilizing agent to avoid aggregation in green synthesis from Ziziphus spinachristi and Garcinia kola . Transmission electron microscopy (TEM) was used to determine particle size and shape. Disc diffusion technique was used to study the susceptibility patterns of the particles on the test organisms- Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa and Staphylococcus aureus. Result: The nanoparticles exhibited very high activity against the pathogens at very low concentration and showed remarkable higher activity than the crude extracts and standard antibiotics (control) with very wide zones of inhibition. The zones of inhibition ranged from 12.4±0.11 – 15.1±0.22 for the nanoparticles as against, 8.7±0.21 – 9.2±0.32 for the crude and 10.7±0.22 – 12.7±0.88 for the standard antibiotics. Conclusion: Green synthesis of silver nanoparticles may give the long awaited breakthrough against these infectious agents to ameliorate, if not completely, win the war against these pathogens.
机译：背景：在过去的二十年中，由于传染病原体对正统药物产生抗药性，因此它们变得更加危险，尤其是在发展中国家。这些国家中的许多人正遭受这些病原体的破坏性影响，而没有任何补救措施。来自药用植物的纳米粒子的最新研究似乎正在产生积极的结果。方法：我们从AgNO 3 进行银纳米粒子的合成，并使用透明质酸作为稳定剂，以防止菠菜和藤黄绿色合成中的聚集。透射电子显微镜（TEM）用于确定粒度和形状。圆盘扩散技术用于研究颗粒在测试微生物（大肠杆菌，伤寒沙门氏菌，铜绿假单胞菌和金黄色葡萄球菌）上的敏感性模式。结果：纳米颗粒在极低的浓度下对病原体表现出非常高的活性，并且比粗提取物和标准抗生素（对照）具有显着更高的活性，并具有很宽的抑制范围。纳米颗粒的抑制范围为12.4±0.11 – 15.1±0.22，而粗品为8.7±0.21 – 9.2±0.32，标准抗生素为10.7±0.22 – 12.7±0.88。结论：银纳米颗粒的绿色合成可能为人们带来期待已久的突破，以缓解这些传染病，即使不是完全缓解，也可以赢得对抗这些病原体的战争。

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