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A model of Engineering Materials Inspired by Biological Tissues

机译:受生物组织启发的工程材料模型

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摘要

The perfect ability of living tissues to control and adapt their mechanical properties to varying external conditions may be an inspiration for designing engineering materials. An interesting example is the smooth muscle tissue since this “material” is able to change its global mechanical properties considerably by a subtle mechanism within individual muscle cells. Multi-scale continuum models may be useful in designing essentially simpler engineering materials having similar properties. As an illustration we present the model of an incompressible material whose microscopic structure is formed by flexible, soft but incompressible balls connected mutually by linear springs. This simple model, however, shows a nontrivial nonlinear behavior caused by the incompressibility of balls and is very sensitive on some microscopic parameters. It may elucidate the way by which “small” changes in biopolymer networks within individualmuscular cells may control the stiffness of the biological tissue, which outlines a way of designing similar engineering materials. The ‘balls and springs’ material presents also prestress-induced stiffening and allows elucidating a contribution of extracellular fluids into the tissue’s viscous properties.
机译:活组织控制和适应其机械性能以适应各种外部条件的完美能力可能是设计工程材料的灵感。一个有趣的例子是平滑肌组织,因为这种“材料”能够通过单个肌肉细胞内的微妙机制极大地改变其整体机械性能。多尺度连续体模型可能在设计具有相似特性的实质上更简单的工程材料时很有用。作为说明,我们介绍了一种不可压缩材料的模型,其微观结构由通过线性弹簧相互连接的柔性,柔软但不可压缩的球形成。但是,这个简单的模型显示了由球的不可压缩性引起的非平凡的非线性行为,并且对某些微观参数非常敏感。它可以阐明单个肌肉细胞内生物聚合物网络中“小的”变化可以控制生物组织刚度的方式,这概述了设计类似工程材料的方式。 “球和弹簧”材料还表现出预应力引起的变硬,并可以阐明细胞外液对组织的粘性的影响。

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