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首页> 外文期刊>Archives of Biological Sciences >MAST CELLS AS KEY PLAYERS IN PERIODONTAL DISEASE
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MAST CELLS AS KEY PLAYERS IN PERIODONTAL DISEASE

机译：肥大细胞是牙周疾病的关键因素

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Mast cell (MC) active mediators promote inflammation through changes induced in the connective tissue components of human gingiva. The aim of this study was to evaluate the distribution, mast cell density and their relationship with the degree of inflammatory infiltrate in gingiva from patients with periodontal disease. Thirty-nine cases with periodontal disease and 12 cases without significant changes to the gingival mucosa were investigated. MCs were identified on paraffin-embedded specimens by immunohistochemistry using anti-mast cell tryptase. The inflammatory infiltrate was scored from 0 to 3, and the MCs were counted using the hotspot method. Intraepithelial MCs were scored from 0 to 2. We found a significant increase of mast cell density in cases with mild and moderate inflammatory changes, and a slight decrease in patients with severe periodontal disease. We noticed a higher degranulation rate in patients with periodontal disease compared to those with healthy mucosa. Intraepithelial MCs were found in cases with periodontal disease only and were correlated with the severity of the inflammatory lesion. MCs are important cellular components of the early stages of periodontal disease. Contrary to other studies, we found that MC density and activation increases with moderate inflammation but decreases in severe inflammatory lesions. Our data suggest that MCs are key players in the progression of inflammatory lesions of the gingiva. In advanced-stage periodontal disease, intraepithelial MCs apparently play an important role, although their biological significance remains to be fully understood.
机译：肥大细胞（MC）活性介质通过在人类牙龈的结缔组织成分中引起的变化促进炎症。这项研究的目的是评估牙周病患者牙龈的分布，肥大细胞密度及其与炎性浸润程度的关系。调查了39例牙周病和12例牙龈粘膜无明显变化的病例。使用抗肥大细胞类胰蛋白酶通过免疫组织化学在石蜡包埋的标本上鉴定MC。炎性浸润的评分为0到3，并使用热点方法对MC进行计数。上皮内MC评分为0到2。我们发现，在轻度和中度炎症改变的情况下，肥大细胞密度显着增加，而在严重牙周疾病的患者中则略有下降。我们注意到，与健康黏膜相比，牙周病患者的脱粒率更高。仅在牙周疾病的病例中发现上皮内MC，并且与炎性病变的严重程度相关。 MC是牙周疾病早期的重要细胞成分。与其他研究相反，我们发现MC密度和激活随着中度炎症而增加，但在严重炎症病变中降低。我们的数据表明，MCs是牙龈炎性病变进展的关键因素。在晚期牙周疾病中，尽管其生物学意义尚待充分了解，上皮内MC显然起着重要作用。

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