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首页> 外文期刊>Archives of Biological Sciences >DISTRIBUTION OF MACROLIDE-RESISTANT GENES AMONG ISOLATES OF MACROLIDERESISTANT STREPTOCOCCUS PYOGENES AND STREPTOCOCCUS PNEUMONIAE IN SERBIA
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DISTRIBUTION OF MACROLIDE-RESISTANT GENES AMONG ISOLATES OF MACROLIDERESISTANT STREPTOCOCCUS PYOGENES AND STREPTOCOCCUS PNEUMONIAE IN SERBIA

机译：耐大环杀链球菌脓杆菌和肺炎链球菌分离株中耐大环杀基因的分布

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Macrolide resistance in Streptococcus pneumoniae and in group A streptococci (GAS) is a significant problem worldwide. In Serbia, data on the mechanisms of resistance and the corresponding resistance genes in streptococci are largely lacking. Therefore, we analyzed the distribution of macrolide resistance phenotypes and genotypes in 44 macrolideresistant GAS (MRGAS) and 50 macrolide-resistant S. pneumoniae (MRSP) isolates collected in the same period. The double disk diffusion test and PCR were used to analyze resistance phenotypes and resistance genes, respectively. Among MRSP, the MLSB phenotype dominated, whereas the M phenotype was the most prevalent among MRGAS isolates. Consequently, in MRSP, the ermB gene was the most common (n=40, 80%), followed by the mefA gene (n=7,14%). In MRGAS strains, mefA dominated (n=27, 61%), followed by ermA (n=15, 33%) and ermB (n=3, 7%). In 3 MRSP isolates no resistance genes were detected, while one MRGAS strain with iMLSB phenotype harbored both ermA and mefA genes.
机译：肺炎链球菌和A组链球菌（GAS）中的大环内酯类耐药性是世界范围内的重要问题。在塞尔维亚，关于链球菌的耐药机制和相应的耐药基因的数据十分缺乏。因此，我们分析了同期收集的44个大环内酯抗性GAS（MRGAS）和50个大环内酯抗性肺炎链球菌（MRSP）分离株的大环内酯抗性表型和基因型的分布。双盘扩散试验和PCR分别用于分析抗性表型和抗性基因。在MRSP中，MLSB表型占主导，而MRGAS分离株中M表型最普遍。因此，在MRSP中，ermB基因是最常见的（n = 40，80％），其次是mefA基因（n = 7.14％）。在MRGAS菌株中，mefA占主导地位（n = 27，61％），其次是ermA（n = 15，33％）和ermB（n = 3，7％）。在3个MRSP分离株中，未检测到抗性基因，而一个具有iMLSB表型的MRGAS菌株同时具有ermA和mefA基因。

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