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首页> 外文期刊>Archives of Biological Sciences >COMPARATIVE PHYLOGENETIC ANALYSIS OF DOBRAVA-BELGRADE VIRUS L AND S GENETIC SEGMENTS ISOLATED FROM AN ANIMAL RESERVOIR IN SERBIA
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COMPARATIVE PHYLOGENETIC ANALYSIS OF DOBRAVA-BELGRADE VIRUS L AND S GENETIC SEGMENTS ISOLATED FROM AN ANIMAL RESERVOIR IN SERBIA

机译：从塞尔维亚动物水库中分离出的斑马鱼-贝类病毒和S基因段的比较系统发育分析

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摘要

The Dobrava-Belgrade virus (DOBV) is a member of the Bunyaviridae family, genus Hantavirus, possessing a single-stranded RNA genome consisting of three segments, designated L (large), M (medium) and S (small). In this study, we present phylogenetic analysis of a newly detected DOBV strain isolated from Apodemus agrarius. Analysis was based on partial L and S segment sequences, in comparison to previously published DOBV sequences from Serbia and elsewhere. A phylogenetic tree based on partial S segment revealed local geographical clustering of DOBV sequences from Serbia, unrelated to host (rodent or human). The topology of the phylogenetic tree was confirmed with a high percent of completely or partially resolved quartets in likelihood-mapping analysis, whereas no evidence of possible recombination in the examined S segment data set was found.
机译：多布拉瓦-贝尔格莱德病毒（DOBV）是汉亚病毒属Bunyaviridae家族的成员，拥有单链RNA基因组，该基因组由三个部分组成，分别为L（大），M（中）和S（小）。在这项研究中，我们提出了从黑线姬鼠分离的新检测到的DOBV菌株的系统发育分析。与先前发布的来自塞尔维亚和其他地方的DOBV序列相比，分析基于部分L和S片段序列。基于部分S片段的系统树揭示了来自塞尔维亚的DOBV序列的本地地理集群，与宿主（啮齿动物或人类）无关。系统发育树的拓扑结构在似然图分析中被高比例的完全或部分分解的四元组所证实，而在所检查的S段数据集中未发现可能重组的证据。

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