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首页> 外文期刊>Archives of Biological Sciences >HYPERHOMOCYSTEINEMIA IN PATIENTS WITH PULMONARY EMBOLISM
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HYPERHOMOCYSTEINEMIA IN PATIENTS WITH PULMONARY EMBOLISM

机译：肺栓塞症患者的高半胱氨酸血症

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Investigation of hyperhomocysteinemia (HHcy) as an important risk factor for pulmonary thromboembolism (PTE), which represents a most dangerous consequence of a unique phenomenon of venous thromboembolism which still suffers from sometimes conflicting or inadequately clarified results. The role of homocysteine in the clinical manifestation of this life-threatening disease and its treatment (in which any further information may be decisive) requires detailed examination.The purpose of this study is to determine the differences in HHcy incidence and homocysteinemia levels between patients with PTE and healthy persons. The study enrolled 70 patients with PTE and 50 healthy persons. Homocysteine was measured using the HPLC method with fluorescent detection and HHcy was defined as homocysteinemia above 12 μmol/L. Statistical analyses included chi-square and Mann Whitney U tests. The median homocysteinemia value was significantly higher (p=0.017) in the patients (12.10 μmol/L) than in the controls (10.35 μmol/L). The comparison of HHcy incidence between the patients (51.5%) and controls (30%) revealed a significant difference (p=0.021). In patients, homocysteinemia was significantly higher (p=0.002) in men (14.05μmol/L) than in women (10.01 μmol/L). HHcy was present in 67.6% of men with PTE, which was significantly higher (p=0.006) than the incidence in women with PTE (33.3%). Healthy males had significantly higher (p=0.001) homocysteinemia (12.54 μmol/L) than healthy females (9.4 μmol/L). A significant difference (p=0.031) was observed between the incidences of HHcy in healthy males (44.0%) and healthy females (16.0%).We conclude that the incidence of hyperhomocysteinemia and homocysteinemia are significantly higher in all the patients compared with the healthy persons, as well as in both healthy males and males with PTE compared with healthy females and female patients. This indicates that HHcy findings in PE are likely to have a clinical importance.
机译：高同型半胱氨酸血症（HHcy）作为肺血栓栓塞（PTE）的重要危险因素的研究，代表了静脉血栓栓塞的独特现象的最危险结果，该现象有时仍会产生矛盾或不明确的结果。同型半胱氨酸在这种危及生命的疾病的临床表现及其治疗中的作用（其中可能有进一步的信息可能是决定性的）需要详细检查。本研究的目的是确定高半胱氨酸患者之间HHcy发生率和高半胱氨酸水平的差异。 PTE和健康人。该研究招募了70名PTE患者和50名健康人。使用具有荧光检测功能的HPLC方法测量同型半胱氨酸，HHcy定义为高于12μmol/ L的高半胱氨酸血症。统计分析包括卡方检验和曼惠特尼U检验。患者（12.10μmol/ L）的半胱氨酸血症中位数值显着高于对照组（10.35μmol/ L）（p = 0.017）。患者（51.5％）和对照组（30％）的HHcy发生率比较显示出显着差异（p = 0.021）。在患者中，男性（14.05μmol/ L）的高半胱氨酸血症明显高于女性（10.01μmol/ L）（p = 0.002）。在PTE的男性中，HHcy占67.6％，显着高于PTE的女性（33.3％）（p = 0.006）。健康男性的同型半胱氨酸血症（12.54μmol/ L）明显高于健康女性（9.4μmol/ L）（p = 0.001）。健康男性（44.0％）和健康女性（16.0％）的HHcy发生率之间存在显着差异（p = 0.031）。我们得出结论，所有患者的高同型半胱氨酸血症和高半胱氨酸血症的发生率均显着高于健康人群与健康女性和女性患者相比，健康男性和PTE男性均如此。这表明在PE中HHcy的发现可能具有临床重要性。

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