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首页> 外文期刊>Archives of Applied Science Research >Effect of Efavirenz and Ritonavir on the pharmacokinetics of Losartan
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Effect of Efavirenz and Ritonavir on the pharmacokinetics of Losartan

机译：依法韦仑和利托那韦对氯沙坦药代动力学的影响

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Drug interactions have become an increasingly complex challenge for treating patients with HIV infection. The present study was to evaluate the effect of efavirenz and ritonavir have any influence on the pharmacokinetics of losartan. Oral treatments of rat with efavirenz [100mg/kg] from days 1 to 13 days. On 14th day administration of efavirenz followed by Losartan [10mg/Kg] after 30 minutes. In addition ritonavir [100mg/Kg] followed similarly as efavirenz on 14th day administration of ritonavir + losartan followed after 30 minutes. Samples were estimated by reverse phase HPLC- UV method. Our study results shows that single dose of studies of efavirenz with losartan increase the bioavailability of Losartan in smaller amounts. In multiple dose studies efavirenz decrease the bioavailability of Losartan there by decrease the antihypertensive effect. Whereas, ritonavir produces antagonist effect. Hence, we conclude that drug interaction takes place with antiretroviral drug Incombination with antihypertensive therapy. In future, our clinical research with HIV patients to confirm the possibility of drug-drug interactions.
机译：药物相互作用已成为治疗HIV感染患者日益复杂的挑战。本研究旨在评估依非韦伦和利托那韦对洛沙坦药代动力学的影响。从第1天到第13天口服依非韦伦[100mg / kg]对大鼠进行口服治疗。在第14天给药30分钟后，依法韦仑，接着是氯沙坦[10mg / Kg]。此外，利托那韦[100mg / Kg]与依非韦伦类似，在第30天后第14天服用利托那韦+氯沙坦。通过反相HPLC-UV方法估计样品。我们的研究结果表明，单剂量的依法韦仑与氯沙坦的研究单剂量增加了氯沙坦的生物利用度。在多剂量研究中，依非韦伦通过降低降压作用来降低洛沙坦的生物利用度。而利托那韦产生拮抗作用。因此，我们得出结论，药物与抗逆转录病毒药物合并和降压治疗发生相互作用。将来，我们将与HIV患者进行临床研究，以确认药物相互作用的可能性。

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