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首页> 外文期刊>Arab Journal of Urology >Outcome of α-blockers, with or without methylprednisolone combination, in medical expulsive therapy for lower ureteric stones: A prospective randomised study
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Outcome of α-blockers, with or without methylprednisolone combination, in medical expulsive therapy for lower ureteric stones: A prospective randomised study

机译：α-受体阻滞剂联合或不联合甲泼尼龙治疗在输尿管下段结石的药物治疗中的结果：一项前瞻性随机研究

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Objectives To compare the safety and efficacy of tamsulosin, alfuzosin, and their combinations with methylprednisolone, in the medical management of lower ureteric stones. Patients and methods Between September 2012 and June 2014, patients diagnosed with a single lower ureteric stone of ?10 mm (longest dimension) were enrolled. Patients with urinary tract infection, severe hydronephrosis, pregnancy, hypertension, diabetes, ulcer disease, or renal insufficiency were excluded. According to the medication added to the analgesic anti-inflammatory, patients were stratified into four groups, with 53 patients in each. Group I patients received tamsulosin 0.4 mg and those in Group II received tamsulosin 0.4 mg and methylprednisolone 8 mg. Group III patients received alfuzosin 10 mg and those in Group IV received alfuzosin 10 mg and methylprednisolone 8 mg. Treatment was continued until stone expulsion or to a maximum of 2 weeks. The patients’ demographics, stone criteria, and stone-free rates were calculated and analysed. Results The mean (SD) maximum stone dimension was 7.8 (1.5), 8.1 (1.3), 7.9 (1.6) and 8.0 (1.4) mm in Groups I, II, III and IV, respectively. Groups II and IV had significantly higher stone-free rates than Groups I and III ( P 0.05), whilst there were no statistically significant differences between Groups I and III or between Groups II and IV. There was no statistical difference among the four groups for the time to stone expulsion. Three patients in Group II and two patients in Group IV developed transient hyperglycaemia, which resolved after cessation of methylprednisolone. Conclusions The combination of alfuzosin or tamsulosin with methylprednisolone seems to be effective and safe for managing lower ureteric stones of 1 cm.
机译：目的比较坦索罗辛，阿夫唑嗪及其与甲基泼尼松龙的组合在下输尿管结石的医疗管理中的安全性和有效性。患者和方法在2012年9月至2014年6月之间，纳入了被诊断患有单个下段输尿管结石10mm（最长尺寸）的患者。排除患有尿路感染，严重肾积水，妊娠，高血压，糖尿病，溃疡病或肾功能不全的患者。根据止痛消炎药的使用情况，将患者分为四组，每组53例。 I组患者接受坦索罗辛0.4 mg，II组患者接受坦索罗辛0.4 mg和甲基强的松龙8 mg。第三组患者接受阿夫唑嗪10 mg，第四组患者接受阿夫唑嗪10 mg和甲基泼尼松龙8 mg。持续治疗直至排出结石或最多2周。计算并分析了患者的人口统计学，结石标准和无结石率。结果I，II，III和IV组的平均最大石尺寸分别为7.8（1.5），8.1（1.3），7.9（1.6）和8.0（1.4）mm。第二和第四组的无结石率明显高于第一和第三组（P <0.05），而第一和第三组之间或第二和第四组之间无统计学差异。四组结石排出时间之间无统计学差异。 II组中的3例患者和IV组中的2例患者出现暂时性高血糖，甲基强的松龙停药后症状消失。结论阿夫唑嗪或坦洛新与甲基强的松龙联合治疗对＜1 cm的下输尿管结石似乎是安全有效的。

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