...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of disease in childhood >Nocturnal haemoglobin oxygen desaturation in urban and rural East African paediatric cohorts with and without sickle cell anaemia: a cross-sectional study
【24h】

Nocturnal haemoglobin oxygen desaturation in urban and rural East African paediatric cohorts with and without sickle cell anaemia: a cross-sectional study

机译：有和没有镰状细胞性贫血的东非城市和农村小儿队列中夜间血红蛋白氧饱和度的横断面研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Low haemoglobin oxygen saturation (SpO2) predicts complications in children with sickle cell anaemia (SCA) in the North but there are few data from Africa, where the majority of the patients reside. We measured daytime and overnight SpO2 in children with SCA in routine follow-up clinic, and controls without symptoms of SCA, comparing rural (Kilifi, Kenya) and urban (Dar-es-Salaam, Tanzania) cohorts. Daytime SpO2 was lower in 65 Tanzanian children with SCA (TS; median 97 (IQR 94–100)%); p2 (92 (86–95)%; 87 (78.5–91)%; 90 (83.5–93)% p=0.0001) were lower. The difference between children with SCA persisted after adjustment for haemoglobin (p=0.004). Urban Tanzanian children, with and without SCA, experience greater exposure to low daytime and night-time SpO2 compared with rural Kenyan children with SCA. Possible explanations include differences in the prevalence of obstructive sleep apnoea or asthma, alterations in the oxyhaemoglobin desaturation curve or cardiovascular compromise, for example, to shunting at atrial or pulmonary level secondary to increased pulmonary artery pressure. The fact that non-SCA siblings in the urban area are also affected suggests that environmental exposures, for example, air pollution, nutrition or physical exercise, may play a role. Further studies should determine aetiology and clinical relevance for the SCA phenotype in children resident in Africa.
机译：低血红蛋白氧饱和度（SpO2）预测北部的镰状细胞性贫血（SCA）儿童会出现并发症，但来自非洲的数据很少，大多数患者居住在非洲。我们比较了农村（基利菲（肯尼亚））和城市（坦桑尼亚达累斯萨拉姆）人群，在常规随访诊所中对患有SCA的儿童的白天和夜间SpO2进行了测量，并控制了没有SCA症状的对照。坦桑尼亚65名SCA儿童的白天SpO2较低（TS;中位数为97（IQR 94-100）％）; p2（92（86-95）％; 87（78.5-91）％; 90（83.5-93）％p = 0.0001）较低。调整血红蛋白后，SCA儿童之间的差异仍然存在（p = 0.004）。与肯尼亚农村患有SCA的儿童相比，有或没有SCA的坦桑尼亚城市儿童遭受的白天和夜间SpO2含量降低的风险更大。可能的解释包括阻塞性睡眠呼吸暂停或哮喘患病率的差异，氧合血红蛋白去饱和曲线的改变或心血管疾病的损害，例如，继发于肺动脉压升高的心房或肺水平分流。市区中非SCA兄弟姐妹也受到影响的事实表明，暴露于环境中，例如空气污染，营养或体育锻炼，可能会起作用。进一步的研究应确定非洲居民儿童SCA表型的病因和临床相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号