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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >An overview of nanosomes delivery mechanisms: trafficking, orders, barriers and cellular effects
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An overview of nanosomes delivery mechanisms: trafficking, orders, barriers and cellular effects

机译：纳米脂质体递送机制概述：贩运，订单，障碍和细胞效应

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Abstract This review traces the journey of nanosomes from administration until elimination, and discusses various biological barriers. The nanosomes are imported into the body through different routes and are localized into specified organ, cell, subcellular locations or organelle compartment. The nanosomes delivery to a specific destination depends on the surface chemistry, size, shape and the presence of specific ligands. Endocytosis/exocytosis cycles are involved in the import and export of the nanosomes. The mononuclear phagocytic system and ATP-binding cassette are universal checkpoints for nanosomes trafficking. The gastrointestinal milieu is the checkpoints for orally administered nanosomes. The mucociliary escalator is a specialized obstacle for inhaled nanosomes. Dermally applied nanosomes are tackled by Langerhans cells and keratinocytes. The nanosomes intended for subcellular destinations are mainly intercepted by lysosomes. Thus, nanosomes intended for biological administration must be designed to escape various barriers. The nanosomes affect cells function by alteration of redox status, and calcium signalling, ultimately, they are exocytosed from the cells.
机译：摘要这篇综述追溯了纳米脂质体从给药到消除的过程，并讨论了各种生物学障碍。纳米脂质体通过不同途径导入体内，并定位在特定的器官，细胞，亚细胞位置或细胞器区室。纳米体向特定目的地的递送取决于表面化学，大小，形状和特定配体的存在。内吞/胞吐周期涉及纳米体的导入和导出。单核吞噬系统和ATP结合盒是纳米脂质体运输的通用检查站。胃肠道环境是口服纳米粒的检查点。粘膜纤毛自动扶梯是吸入纳米脂质体的专门障碍。皮肤应用的纳米脂质体由朗格汉斯细胞和角质形成细胞解决。预定用于亚细胞目的地的纳米小体主要被溶酶体截获。因此，必须设计用于生物给药的纳米脂质体以逃避各种障碍。纳米脂质体通过氧化还原状态的改变和钙信号传导影响细胞功能，最终它们从细胞中被胞吐。

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