Gastro retention using polymer cocoons

Julien Arnold; David Hunkeler

首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Gastro retention using polymer cocoons

【24h】

Gastro retention using polymer cocoons

机译：使用聚合物茧保留胃液

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A gastro-retentive capsule has been prepared which is retained in the stomach for a period of 24h, providing a vehicle for the controlled delivery to the upper intestines. These “gastro cocoons” can resist passage through the sphincter of the stomach, and can retain a high drug payload (30%). They are made from oppositely charged polyelectrolytes and can swell to twice their initial volume. They are strong and also can resist 550 N of compressive force. They are based on filled pharmaceutical capsules which are visible to X-rays. Using ambroxol hydrochloride as a model drug linear, zero-order, release curves were obtained.

机译：制备了一种胃-留胶囊，该胃capsule留胶囊在胃中保留了24小时，为控制输送到上肠提供了载体。这些“胃茧”可以抵抗通过胃括约肌的通过，并可以保留较高的药物有效载荷（30％）。它们由带相反电荷的聚电解质制成，可溶胀至其初始体积的两倍。它们很坚固，还可以抵抗550 N的压力。它们基于X射线可见的填充药物胶囊。使用盐酸氨溴索作为模型药物，可得出线性，零级释放曲线。

著录项

来源
《Artificial cells, nanomedicine, and biotechnology.》 |2015年第1期|共7页
作者
Julien Arnold; David Hunkeler;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类医用一般科学;
关键词
drug-deliveryencapsulationgastro-retentionpolyelectrolyte;

机译：药物递送包封胃保留聚电解质;

相似文献

外文文献
中文文献
专利

1. Gastro retention using polymer cocoons [J] . Arnold Julien, Hunkeler David Artificial cells, nanomedicine, and biotechnology. . 2015,第1a6期

机译：使用聚合物茧保留胃液
2. Scientific Opinion on the substantiation of health claims related to fructooligosaccharides (FOS) from sucrose and decreasing potentially pathogenic gastro intestinal microorganisms (ID 774), changes in short chain fatty acid (SCFA) production and pH in the gastro‐intestinal tract (ID 775), changes in bowel function (ID 775, 778), reduction of gastro intestinal discomfort (ID 775, 778), increase in calcium and/or magnesium absorption leading to an increase in magnesium and/or calcium retention (ID 776, 777), maintenance of normal blood LDL cholesterol concentrations (ID 805) and maintenance of normal (fasting) blood concentrations of triglycerides (ID 805) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2011,第4期

机译：关于证实来自蔗糖的低聚果糖（FOS）和减少潜在致病性胃肠道微生物（ID 774），短链脂肪酸（SCFA）产量和胃肠道pH（ID 775）变化的健康主张的科学意见，肠功能的改变（ID 775、778），肠胃不适的减轻（ID 775、778），钙和/或镁吸收的增加导致镁和/或钙retention留的增加（ID 776、777），根据法规（EC）第1924/2006号第13（1）条，维持正常血液LDL胆固醇浓度（ID 805）和维持正常（禁食）甘油三酸酯浓度（ID 805）
3. Effect of Hydrophobic Polymers on the Gastro Retention Time and In vitro Release of Ciprofloxacin HCl from Co-matrix Tablets [J] . Muhammad Shahidul Islam, Kumar Bishwajit Sutradhar, Jakir Ahmed Chowdhury, Dhaka University Journal of Pharmaceutical Sciences . 2010,第2期

机译：疏水性聚合物对复方片剂胃肠道保留时间和盐酸环丙沙星体外释放的影响
4. Formulation And Evaluation Of Sustained Release Orally Disintegrating Tablets OfMetoclopramide Hydrochloride Intended For Gastro retention [C] . Shidhaye.S, Malke .S, Kadam.V, Annual meeting exposition of the Controlled Release Society . 2009

机译：胃胃retention留用盐酸甲氧氯普胺缓释口腔崩解片的研制与评价
5. Evaluation of hydrophilic polymers for applicability to swellable gastro-retentive drug delivery systems. [D] . Matharu, Amol S. 2010

机译：评估亲水性聚合物在可溶胀的胃滞留性药物递送系统中的适用性。
6. Design and fabrication of flexible DNA polymer cocoons to encapsulate live cells [O] . Tao Gao, Tianshu Chen, Chang Feng, -1

机译：设计和制造可包裹活细胞的柔性DNA聚合物茧
7. Comparison of Gastro Retention Time and in vitro Release Profile studies of Ciprofloxacin HCl from Co-matrix Tablets of Hydrophilic Polymers [O] . Muhammad Shahidul Islam, Kazi Rashidul Azam, Jakir Ahmed Chowdhury, 2014

机译：亲水性聚合物共基质片剂中盐酸环丙沙星的胃保留时间和体外释放曲线研究的比较

Gastro retention using polymer cocoons

摘要

著录项

相似文献

相关主题

期刊订阅