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Role of reactive oxygen species in male infertility: An updated review of literature

机译：活性氧在男性不育症中的作用：文献综述

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Objectives To review the literature and provide an updated summary on the role of reactive oxygen species (ROS) in male infertility. Methods A review of PubMed, Cochrane review, and Web of Science databases for full-text English-language articles published between 1943 and 2017 was performed, focusing on the aetiology of ROS, physiological role of ROS on spermatic function, pathological role of ROS in infertility, evaluation of ROS, and role of antioxidants in oxidative stress. Results ROS play a role in spermatic function and fertilisation. The literature describes both a physiological and a pathological role of ROS in fertility. A delicate balance between ROS necessary for physiological activity and antioxidants to protect from cellular oxidative injury is essential for fertility. Conclusion Although elevated levels of ROS are implicated as a cause of infertility, there is no consensus on selecting patients to test for ROS, which test to perform, or if treatment for ROS can have a positive impact on infertility rates and pregnancy.
机译：目的回顾文献并提供有关活性氧（ROS）在男性不育症中的作用的最新综述。方法回顾了1943年至2017年间发表的全文英语文章的PubMed，Cochrane评论和Web of Science数据库，重点研究了ROS的病因，ROS在精子功能中的生理作用，ROS在精子中的病理作用。不育，ROS评估以及抗氧化剂在氧化应激中的作用。结果ROS在精子功能和受精中起作用。文献描述了ROS在生育中的生理和病理作用。生理活动所必需的ROS和保护免受细胞氧化损伤的抗氧化剂之间的微妙平衡对于生育至关重要。结论尽管ROS水平升高可能是导致不孕的原因，但在选择患者进行ROS测试，进行何种测试或治疗ROS是否对不孕率和妊娠产生积极影响方面尚无共识。

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