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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Upcycling of jellyfish ( Nemopilema nomurai ) sea wastes as highly valuable reducing agents for green synthesis of gold nanoparticles and their antitumor and anti-inflammatory activity
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Upcycling of jellyfish ( Nemopilema nomurai ) sea wastes as highly valuable reducing agents for green synthesis of gold nanoparticles and their antitumor and anti-inflammatory activity

机译：水母（Nemopilema nomurai）海废料的升级换代是用于绿色合成金纳米粒子及其抗肿瘤和消炎活性的极有价值的还原剂

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Due to its tentacle poison and huge body, giant jellyfish (Nemopilema nomurai) poses challenging issues to the environment and ecosystems. Here we developed, upcycling a giant jellyfish extract as a reducing agent, a green synthetic method of gold nanoparticles (JF-AuNPs) which possess biological activities. The colloidal solutions of JF-AuNPs were blue, violet, purple and pink depending on the extract concentration. UV-visible spectra exhibited two surface plasmon resonance bands at 5 4 0?～?550?nm and 810?nm. Spherical shapes with an average size of 35.2?±?8.7?nm and triangular nanoplates with an average height of 70.5?±?30.3?nm were observed. A face-centered cubic structure was confirmed by high-resolution X-ray diffraction. JF-AuNPs exhibited significant cytotoxic effect against HeLa cancer cells but not against normal cells such as NIH-3T3 and Raw 264.7 cells. In HeLa cells, JF-AuNPs decreased the phosphorylation of AKT and ERK, which are crucial for cell proliferation. Also, JF-AuNPs decreased NO secretion and iNOS expression levels, resulting in anti-inflammatory effects in LPS-inflamed macrophages. Collectively, we established a green synthesis of anti-tumorigenic and anti-inflammatory JF-AuNPs using the extract of jellyfish sea wastes. Thus, beneficial effects of JF-AgNPs must be weighed in further studies in vivo and it can be potent nanomedicine for future applications.
机译：由于其触手毒药和巨大的身体，巨型水母（Nemopilema nomurai）对环境和生态系统构成了具有挑战性的问题。在这里，我们开发了一种大型水母提取物作为还原剂，并对其进行了升级改造，这是一种具有生物活性的金纳米颗粒（JF-AuNPs）的绿色合成方法。根据提取物的浓度，JF-AuNPs的胶体溶液为蓝色，紫色，紫色和粉红色。紫外可见光谱在5 40λ〜550λnm和810λnm处有两个表面等离子体共振带。观察到平均大小为35.2±±8.7纳米的球形和三角形纳米板的平均高度为70.5±±30.3纳米。通过高分辨率X射线衍射确认了面心立方结构。 JF-AuNP对HeLa癌细胞显示出显着的细胞毒性作用，但对正常细胞（如NIH-3T3和Raw 264.7细胞）则没有。在HeLa细胞中，JF-AuNPs降低了AKT和ERK的磷酸化，这对于细胞增殖至关重要。同样，JF-AuNPs减少NO分泌和iNOS表达水平，从而导致LPS刺激的巨噬细胞具有抗炎作用。总的来说，我们使用水母海废提取物建立了抗肿瘤和消炎JF-AuNP的绿色合成方法。因此，在体内进一步研究中必须权衡JF-AgNP的有益作用，它对于未来的应用可能是有效的纳米药物。

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