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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Capsaicin delivery into the skin with lipidic nanoparticles for the treatment of psoriasis
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Capsaicin delivery into the skin with lipidic nanoparticles for the treatment of psoriasis

机译：辣椒素与脂质纳米颗粒一起输送到皮肤中以治疗牛皮癣

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The study aims to explore the potential of solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) in improving the topical delivery of capsaicin (CAP) by in vitro and in vivo studies. The lipidic nanoparticles were prepared by solvent diffusion method and were characterized for average particle size, zeta potential and entrapment efficiency. TEM photomicrographs revealed that the particles were nanometric in size. Higher amount of CAP can be encapsulated in the NLCs (87.4 ± 3.28) as compared with SLNs (79.7 ± 2.93%). The cumulative amounts of CAP permeated through the skin and retained in the SC were higher in the case of NLCs as compared with plain drug solution and SLNs. SLNs and NLCs exhibited minimum to no irritation. All the results concluded that NLCs and SLNs have shown a good ability to increase drug accumulation in the various skin layers but NLCs may be a more potential carrier for topical delivery of CAP for an effective therapy of psoriasis.
机译：这项研究旨在通过体外和体内研究探索固体脂质纳米颗粒（SLN）和纳米结构脂质载体（NLC）在改善辣椒素（CAP）局部递送方面的潜力。通过溶剂扩散法制备脂质纳米颗粒，并表征其平均粒径，ζ电势和包封效率。 TEM显微照片显示，颗粒尺寸为纳米级。与SLN（79.7±2.93％）相比，NLC中可以封装更多的CAP（87.4±3.28）。与普通药物溶液和SLNs相比，在NLC中，透过皮肤并保留在SC中的CAP累积量更高。 SLN和NLC表现出最小的刺激或无刺激。所有结果均得出结论，NLC和SLNs已显示出良好的能力来增加药物在各种皮肤层中的蓄积，但NLCs可能是用于局部递送CAP的更有效治疗牛皮癣的载体。

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