PK11195, A Specific Ligand of the Peripheral Benzodiazepine Receptor, May Protect Pancreatic Beta-cells from Cytokine-induced Cell Death

Roland A. Klaffschenkel; Marc Waidmann; Hinnak Northoff; Amr A. A. Mahmoud; Nicolas Lembert

首页> 外文期刊>Artificial cells, blood substitutes, and immobilization biotechnology. >PK11195, A Specific Ligand of the Peripheral Benzodiazepine Receptor, May Protect Pancreatic Beta-cells from Cytokine-induced Cell Death

【24h】

PK11195, A Specific Ligand of the Peripheral Benzodiazepine Receptor, May Protect Pancreatic Beta-cells from Cytokine-induced Cell Death

机译：PK11195，外围苯二氮杂ze受体的特定配体，可以保护胰腺β细胞免受细胞因子诱导的细胞死亡。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We cultured isolated islets from human or porcine origin in the presence or absence of IL1 and TNFα and studied cytoprotective effects of two structurally different PBR ligands. Storage of pig or human islets in the presence of cytokines significantly lowered the fraction of vital beta-cells. Compared with cytokine incubations PK11195 alone or in combination with cytokines was effective to prevent cytokine induced cell death. The data indicate that cold storage in the presence of PK11195 may further protect beta-cells from cytokine induced cell death. This ligand may be helpful to preserve beta-cell survival before transplantation.

机译：我们在存在或不存在IL1和TNFα的情况下培养了从人或猪源分离的胰岛，并研究了两种结构不同的PBR配体的细胞保护作用。在存在细胞因子的情况下，猪或人胰岛的储存显着降低了重要β细胞的比例。与细胞因子孵育相比，单独或与细胞因子联合使用PK11195可以有效防止细胞因子诱导的细胞死亡。数据表明在PK11195存在下的冷藏可以进一步保护β细胞免受细胞因子诱导的细胞死亡。这种配体可能有助于在移植前保持β细胞的存活。

著录项

来源
《Artificial cells, blood substitutes, and immobilization biotechnology.》 |2012年第2期|共6页
作者
Roland A. Klaffschenkel; Marc Waidmann; Hinnak Northoff; Amr A. A. Mahmoud; Nicolas Lembert;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类生物医学工程;
关键词
CytokinesIsletsIslet isolationIslet transplantationPBR ligands;

机译：细胞因子胰岛胰岛分离胰岛移植PBR配体;

相似文献

外文文献
中文文献
专利

1. PK11195, A Specific Ligand of the Peripheral Benzodiazepine Receptor, May Protect Pancreatic Beta-cells from Cytokine-induced Cell Death [J] . Rol A. Klaffschenkel, Marc Waidmann Hinnak Northoff Artificial cells, blood substitutes, and immobilization biotechnology . 2012,第2期

机译：PK11195，外围苯二氮杂ze受体的特定配体，可能保护胰腺β细胞免受细胞因子诱导的细胞死亡。
2. PK11195, a specific ligand of the peripheral benzodiazepine receptor, May protect pancreatic beta-cells from cytokine-induced cell death [J] . KlaffschenkelR.A., WaidmannM., NorthoffH., Artificial cells, blood substitutes, and immobilization biotechnology . 2012,第1a2期

机译：PK11195，外周苯二氮卓类受体的特定配体，可能保护胰腺β细胞免受细胞因子诱导的细胞死亡
3. PK11195, a specific ligand of the peripheral benzodiazepine receptor, may protect pancreatic beta-cells from cytokine-induced cell death. [J] . Roland A Klaffschenkel, Marc Waidmann, Hinnak Northoff, Artificial cells, blood substitutes, and biotechnology . 2012,第1a2期

机译：外周苯并二氮杂receptor受体的特定配体PK11195可以保护胰腺β细胞免受细胞因子诱导的细胞死亡。
4. Peripheral benzodiazepine receptor ligand-PLGA polymer conjugates potentially useful asdelivery systems of apoptoticeuroactive agents [C] . V. Laquintana, N. Denora, A. Latrofa, Annual meeting exposition of the Controlled Release Society . 2009

机译：外周苯并二氮杂receptor受体配体-PLGA聚合物共轭物可能对凋亡/神经活性剂的递送系统有用
5. Synthesis of peripheral benzodiazepine receptor ligand as a molecular carrier of platinum and the PBR ligand-platinum complex as a potential anti-cancer agent. [D] . Tosado Marzan, Mariela. 2005

机译：合成周围的苯并二氮杂receptor受体配体作为铂的分子载体，并合成PBR配体-铂配合物作为潜在的抗癌剂。
6. PK11195 a peripheral benzodiazepine receptor (pBR) ligand broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent direct transporter-modulating mechanism [O] . Roland B. Walter, Jason L. Pirga, Michelle R. Cronk, -1

机译：PK11195是一种外周苯并二氮杂（受体（pBR）配体通过独立于pBR的直接转运蛋白调节机制广泛阻断药物外流对白血病和骨髓瘤细胞产生化学敏感性
7. PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism [O] . Walter, Roland B., Pirga, Jason L., Cronk, Michelle R., 2005

机译：PK11195是一种外围苯二氮卓类受体（pBR）配体，通过独立于pBR的直接转运蛋白调节机制广泛阻断药物外流，对白血病和骨髓瘤细胞产生化学敏感性

PK11195, A Specific Ligand of the Peripheral Benzodiazepine Receptor, May Protect Pancreatic Beta-cells from Cytokine-induced Cell Death

摘要

著录项

相似文献

相关主题

期刊订阅