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首页> 外文期刊>Artificial cells, blood substitutes, and immobilization biotechnology. >Increased Inter Dimeric Interaction of Oxy Hemoglobin is Necessary for Attenuation of Redutive Pegylation Promoted Dissociation of Tetramer
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Increased Inter Dimeric Interaction of Oxy Hemoglobin is Necessary for Attenuation of Redutive Pegylation Promoted Dissociation of Tetramer

机译：氧血红蛋白的二聚体间相互作用的增加是必不可少的，以减轻重复聚乙二醇化促进四聚体解离。

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摘要

The propensity of site-specific carboxymethylation and Propylation of Val-1(α) of Hb to attenuate the reductive hexaPEGylation-induced dissociation of tetramers has been investigated. Only reductive Propylation of Val-1(α), which increases the stability of oxy Hb, attenuates the reductive hexaPEGylation-induced dissociation. Increasing the stability of the oxy conformation of Hb by chemical or genetic approaches is a strategy to generate PEGylated Hbs with native-like tetramer stability using direct PEGylation platforms. This new approach and EAF-PEGylation are the only two alternate PEGylation strategies available to design stable second-generation vasoinactive uncrosslinked PEGylated Hbs with native-like tetramer stability.
机译：研究了Hb的位点特异性羧甲基化和Val-1（α）的脯氨酰化减弱还原性hexaPEGylation诱导的四聚体解离的倾向。只有还原性的Val-1（α）丙氧基化可增加oxy Hb的稳定性，才能减弱还原性hexaPEG化的诱导解离。通过化学或遗传方法提高Hb氧构象的稳定性是一种使用直接PEG化平台生成具有天然样四聚体稳定性的PEG化Hb的策略。这种新方法和EAF-PEG化是仅有的两种可替代的PEG化策略，可用于设计具有天然类似四聚体稳定性的稳定的第二代血管活性未交联的PEG化Hb。

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