• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Artificial cells, blood substitutes, and immobilization biotechnology. >Development and Characterization of Rifampicin Loaded Floating Microspheres
【24h】

Development and Characterization of Rifampicin Loaded Floating Microspheres

机译：利福平负载的漂浮微球的研制与表征

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

: Gastroretentive floating microspheres have a potential for enhancing the bioavailability and controlled delivery of drugs. The present study involves development of rifampicin floating microspheres in order to increase the gastric retention time. The microspheres were prepared by solvent evaporation technique and characterized for particle size, shape, zeta-potential, entrapment, and release kinetics. The developed systems were almost spherical in shape. The entrapment efficiency was found to be 86.34%. The percentage buoyancy after 8 hours was found to be 61.06. The prepared microspheres exhibited prolonged drug release in gastric medium and hence could be utilized for sustained delivery of anti-tubercular drugs.
机译：：胃滞留性漂浮微球具有增强生物利用度和控制药物输送的潜力。本研究涉及利福平漂浮微球的开发，以增加胃保留时间。通过溶剂蒸发技术制备微球，并表征其粒径，形状，ζ电势，截留和释放动力学。发达的系统几乎是球形的。发现包封率为86.34％。发现8小时后的浮力百分比为61.06。制备的微球在胃介质中表现出延长的药物释放，因此可用于持续输送抗结核药。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号