Basic Science Offers a Challenge for Developing Hemoglobin Based Oxygen Carriers into Therapeutic Agents

Enrico Bucci

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Basic Science Offers a Challenge for Developing Hemoglobin Based Oxygen Carriers into Therapeutic Agents

机译：基础科学为将基于血红蛋白的氧气载体发展为治疗剂提出了挑战

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: Experimental data, obtained during the course of several years, are connected into a coherent picture, which may help research for the development of HBOCs as therapeutic agents. Oxygen affinity, scavenging of nitric oxide, and yield of production of hemoglobin based oxygen carriers were the areas under consideration.

机译：：几年来获得的实验数据被连成一体，这可能有助于研究将HBOC用作治疗剂。氧亲和力，一氧化氮的清除以及基于血红蛋白的氧载体的产量是考虑的领域。

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《Artificial cells, blood substitutes, and immobilization biotechnology.》 |2011年第4期|共8页
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Enrico Bucci;
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中图分类生物医学工程;
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Blood substitutesoxygen deliveryfacilitate diffusionNO scavengingvasoconstriction;

机译：血液代用品氧输送促进扩散无清除血管收缩;

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1. Basic science offers a challenge for developing hemoglobin based oxygen carriers into therapeutic agents. [J] . Bucci E Artificial cells, blood substitutes, and biotechnology . 2011,第4期

机译：基础科学为将基于血红蛋白的氧载体发展为治疗剂提出了挑战。
2. Basic science offers a challenge for developing hemoglobin based oxygen carriers into therapeutic agents [J] . BucciE. Artificial cells, blood substitutes, and immobilization biotechnology . 2011,第4期

机译：基础科学为将基于血红蛋白的氧载体发展为治疗剂提出了挑战
3. Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier [J] . Current drug discovery technologies . 2012,第3期

机译：开发用于氧气治疗载体的天然细胞外血红蛋白的微循环和NO-CO研究
4. Artificial Oxygen Carriers (Hemoglobin-Vesicles) as a Transfusion Alternative and for Oxygen Therapeutics [C] . H. Sakai 5th Kuala Lumpur international conference on biomedical engineering 2011 . 2011

机译：人工氧气载体（血红蛋白囊泡）作为输血替代品并用于氧气治疗
5. Designing and engineering recombinant hemoglobins as potential hemoglobin-based oxygen carriers. [D] . Tsai, Ching-Hsuan. 2000

机译：设计和改造重组血红蛋白作为潜在的基于血红蛋白的氧气载体。
6. Polymerized human hemoglobin facilitated modulation of tumor oxygenation is dependent on tumor oxygenation status and oxygen affinity of the hemoglobin-based oxygen carrier [O] . Donald A. Belcher, Alfredo Lucas, Pedro Cabrales, -1

机译：聚合人血红蛋白促进肿瘤氧合的调节取决于肿瘤氧合状态和基于血红蛋白的氧载体的氧亲和力
7. Hierarchical Structures of Natural Acellular Polymeric Hemoglobins: Model for Design of a Therapeutic Hemoglobin-Based-Oxygen-Carrier (HBOC) [O] . Harrington John P., Orlik Kseniya, Wollocko Hanna 2009

机译：天然无细胞聚合血红蛋白的层次结构：治疗性基于血红蛋白的氧气载体（HBOC）设计模型
8. Hemoglobin-based Oxygen Carrier, Bovine Polymerized Hemoglobin (HBOC- 201) Versus Hetastarch (HEX) in a Moderate Severity Hemorrhagic Shock Swine Model with Delayed Evacuation [R] . Philbin, N. , Rice, J. , Gurney, J. , 2005

机译：血红蛋白为基础的氧载体，牛聚合的血红蛋白（HBOC- 201）对战羟乙基淀粉（HEX），其与延迟疏散一个中等程度失血性休克模型猪

Basic Science Offers a Challenge for Developing Hemoglobin Based Oxygen Carriers into Therapeutic Agents

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