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首页> 外文期刊>Artificial cells, blood substitutes, and immobilization biotechnology. >Effect of Surfactants on the Characteristics of Fluconazole Niosomes for Enhanced Cutaneous Delivery
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Effect of Surfactants on the Characteristics of Fluconazole Niosomes for Enhanced Cutaneous Delivery

机译：表面活性剂对氟康唑类脂质体增强皮肤递送特性的影响

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: Fluconazole-loaded niosomes were prepared by the film hydration method with different surfactants (Span and Brij series) and characterized for various parameters. Results showed that niosomes composed of Span 40, Span 60, and Brij 72 were most stable with smaller size, i.e. 0.378 ± 0.022 μm, 0.343 ± 0.063 μm, and 0.287 ± 0.012 μm, respectively, along with higher entrapment efficiency (approx. 41%). In vitro skin permeation and retention studies suggested that cutaneous accumulation was affected by surfactant property and vesicle size. Therefore the niosomes consisting of Span 40, Span 60, and Brij 72 surfactant are seemingly accumulated and form localized drug depots in the skin, thereby releasing the contents in a sustained manner and able to greatly enhance cutaneous retention of the drug.
机译：：通过薄膜水合作用不同表面活性剂（Span和Brij系列）制备负载氟康唑的脂质体，并表征各种参数。结果显示，由Span 40，Span 60和Brij 72组成的脂质体最稳定，尺寸更小，分别为0.378±0.022μm，0.343±0.063μm和0.287±0.012μm，并且包封率更高（大约> 41％）。体外皮肤渗透和保留研究表明，皮肤堆积受表面活性剂性质和囊泡大小的影响。因此，由Span 40，Span 60和Brij 72表面活性剂组成的脂质体似乎在皮肤中积聚并形成局部药物贮库，从而以持续的方式释放内含物并能够大大增强药物在皮肤上的保留。

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