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首页> 外文期刊>Artificial cells, blood substitutes, and immobilization biotechnology. >Polyhemoglobin-superoxide Dismutase-catalase-carbonic Anhydrase: A Novel Biotechnology-based Blood Substitute that Transports Both Oxygen and Carbon Dioxide and Also Acts as an Antioxidant
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Polyhemoglobin-superoxide Dismutase-catalase-carbonic Anhydrase: A Novel Biotechnology-based Blood Substitute that Transports Both Oxygen and Carbon Dioxide and Also Acts as an Antioxidant

机译：多聚血红蛋白超氧化物歧化酶-过氧化氢酶-碳酸酐酶：一种基于生物技术的新型血液替代物，既可以运输氧气也可以运输二氧化碳，并且还可以充当抗氧化剂

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Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase (PolyHb-SOD-CAT-CA) is a therapeutic antioxidant that also transports both oxygen and carbon dioxide. This is formed by crosslinking Hb with SOD, CAT, and CA using glutaraldehyde. Crosslinking stroma-free Hb from red blood cell (RBC) reduces CA activity to 55%. Addition of more CA resulted in a preparation with the same CA activity as RBC. PolyHb in the complex acts as a buffer to prevent large pH changes as carbon dioxide is converted to carbonic acid. We then prepare and optimize a novel PolyHb-SOD-CAT-CA, a therapeutic antioxidant that also transports both oxygen and carbon dioxide.
机译：聚血红蛋白-超氧化物歧化酶-过氧化氢酶-碳酸酐酶（PolyHb-SOD-CAT-CA）是一种治疗性抗氧化剂，也可转运氧气和二氧化碳。这是通过使用戊二醛将Hb与SOD，CAT和CA交联形成的。来自红细胞（RBC）的无基质Hb交联可将CA活性降低至55％。添加更多的CA导致制剂的CA活性与RBC相同。复合物中的PolyHb用作缓冲剂，可防止二氧化碳转化为碳酸时pH值发生较大变化。然后，我们准备并优化一种新型的PolyHb-SOD-CAT-CA，这是一种治疗性抗氧化剂，也可以输送氧气和二氧化碳。

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