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首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >EVALUATION OF ANTIHYPERGLYCAEMIC EFFECT OF BUTEA MONOSPERMA LEAF EXTRACT ON ADRENALIN INDUCED AND HIGH GLUCOSE FEED ANIMAL MODEL
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EVALUATION OF ANTIHYPERGLYCAEMIC EFFECT OF BUTEA MONOSPERMA LEAF EXTRACT ON ADRENALIN INDUCED AND HIGH GLUCOSE FEED ANIMAL MODEL

机译：牛精子叶提取物对肾上腺素诱导的高糖饲料动物模型的抗高血糖作用的评价

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Objective: As per the ethnopharmacological information has Butea monosperma been used to treat diabetes mellitus by the tribal people of tropical and subtropical areas. However, there is no much more scientific report available about the antidiabetic property of the leaves of the plant. Hence, the study was undertaken to evaluate the antidiabetic effect of ethanolic extract of B. monosperma on blood levels of adrenaline-induced and glucose feed diabetic rabbits. Methods: The three different doses of the extracts (100, 200, and 400 mg/kg) were administered orally to an experimental animal. The animals were induced diabetics by adrenaline and high glucose diet. Blood glucose level was measured accordingly. For antidiabetic activity, photocolorimeter was used to monitoring the blood glucose level with crest kit box (GOP-POD method). Results: The extracts showed considerable dose-dependent activity. However, the dose 400 mg/kg showed considerable lower of blood glucose level. p<0.01 indicates the significance result. 8 hrs reading 182.5±3.83 for 400 mg does is most effective for reducing blood sugar. Conclusion: The study indicates that the ethanolic extract of B. monosperma leaves possesses antidiabetic properties which suggest the presence of biologically active components.
机译：目的：根据民族药理学信息，热带和亚热带地区的部落人已将单子叶丁香用于治疗糖尿病。然而，关于植物叶子的抗糖尿病特性，没有更多的科学报告可用。因此，进行该研究以评价单精子芽孢杆菌乙醇提取物对肾上腺素诱导的和葡萄糖喂养的糖尿病兔子的血液水平的抗糖尿病作用。方法：将三种不同剂量的提取物（100、200和400 mg / kg）口服给予实验动物。通过肾上腺素和高糖饮食使动物诱发糖尿病。相应地测量血糖水平。对于抗糖尿病活性，使用光度计通过波峰套件盒（GOP-POD方法）监测血糖水平。结果：提取物显示出相当大的剂量依赖性活性。但是，400 mg / kg剂量显示血糖水平明显降低。 p <0.01表示显着性结果。 8小时读数为400 mg时为182.5±3.83，对降低血糖最为有效。结论：该研究表明，单子叶植物的乙醇提取物具有抗糖尿病特性，表明存在生物活性成分。

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