• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >THE ANTIDEPRESSANT DRUG DOXEPIN: A PROMISING ANTIOXIDANT
【24h】

THE ANTIDEPRESSANT DRUG DOXEPIN: A PROMISING ANTIOXIDANT

机译：抗抑郁药多塞平：一种有希望的抗氧化剂

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Oxidative stress contributes to the pathophysiology of exposure to environmental pollutants and to different free radical generating biochemical reactions in a human system leading to various types of age-related ailments. An antioxidant is a substance capable of preventing or slowing down oxidation of other molecules. Administration of different natural or synthetic antioxidants can ably lead to prevention and attenuation of such stress-induced biochemical alterations. Best examples of natural antioxidants are plant-derived flavonoids. The present study has been designated to determine antioxidant properties in antidepressant compound doxepin which is structurally similar to flavonoid quercetin. Methods: Antioxidant capacity in doxepin was determined with help of several standard conventional procedures such as phosphomolybdenum assay, Ferric ion and cupric ion reducing power assays, ferrous ion chelating activity assay, hydrogen peroxide, and nitric oxide scavenging activity assays. Results: Doxepin showed a stable rise in its antioxidant activity in a dose-dependent manner as determined by ferric as well as cupric ion reducing capacity and by phosphomolybdenum assay. An almost identical observation was noted while determining ferrous ion chelating activity. Furthermore, doxepin showed a strong nitric oxide scavenging activity in all the concentrations used in the study while its hydrogen peroxide scavenging activity was only observed at 500 μg/ml of doxepin. Conclusion: Thus, our study opens up a new vista in search for antioxidants not only from plant sources but also from clinically established pharmaceutical compounds that are already in practical use among patients. Keywords: Antioxidant, Antidepressant, Doxepin, Quercetin, Flavanol, Flavonoids.
机译：目的：氧化应激有助于人体环境中暴露的病理生理，并导致人体系统中各种自由基产生的生化反应，从而导致各种类型的与年龄有关的疾病。抗氧化剂是能够防止或减慢其他分子的氧化的物质。施用不同的天然或合成抗氧化剂可以适当地预防和减轻这种应激诱导的生化改变。天然抗氧化剂的最佳例子是植物类黄酮。已经指定本研究来确定抗抑郁化合物多塞平的抗氧化性能，该结构与类黄酮槲皮素相似。方法：借助几种标准的常规程序，如磷钼测定，铁离子和铜离子还原能力测定，亚铁离子螯合活性测定，过氧化氢和一氧化氮清除活性测定，确定了多塞平的抗氧化能力。结果：通过铁，铜离子还原能力和磷钼法测定，多塞平的抗氧化活性呈剂量依赖性稳定增长。在测定亚铁离子螯合活性时，观察到几乎相同的观察结果。此外，在研究中使用的所有浓度下，多塞平都具有很强的一氧化氮清除活性，而仅在500μg/ ml的多塞平下才能观察到其过氧化氢清除活性。结论：因此，我们的研究开辟了新的视野，不仅可以从植物来源中寻找抗氧化剂，还可以从已经在患者中实际使用的临床确定的药物化合物中寻找抗氧化剂。关键字：抗氧化剂，抗抑郁剂，多塞平，槲皮素，黄烷醇，类黄酮。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号